Quantitative Histological Studies on the Pathogenesis of Uremic Bone Disease*
| Autor: | David J. Baylink, Donald J. Sherrard, Jon E. Wergedal, Norma A. Maloney |
|---|---|
| Rok vydání: | 1974 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Time Factors Intermediate form Bone disease Biopsy Endocrinology Diabetes and Metabolism Clinical Biochemistry Osteitis Fibrosa Cystica chemistry.chemical_element Calcium Biochemistry Bone and Bones Pathogenesis Endocrinology Fibrosis Internal medicine medicine Humans Bone Resorption Uremia Bone Development business.industry Biochemistry (medical) Histology Middle Aged medicine.disease Resorption chemistry Parathyroid Hormone Osteomalacia Female Bone Diseases business Calcification |
| Zdroj: | The Journal of Clinical Endocrinology & Metabolism. 39:119-135 |
| ISSN: | 1945-7197 0021-972X |
| DOI: | 10.1210/jcem-39-1-119 |
| Popis: | Twenty-two patients with chronic uremia were separated into 3 groups on the basis of quantitative bone histology: 1) mild (10 patients); 2) osteomalacic (6); and 3) fibrotic (6). In the mild group there was an increase in forming surface; in the osteomalacic group, a delayed onset of mineralization; in the fibrotic group, increases in marrow fibrosis, bone formation and resorption. Since duration of renal disease was much shorter in the mild group, it was considered a precursor of the other 2 groups. In addition there were positive correlations between a number of bone parameters and duration of renal disease. Since duration of renal disease was similar in the osteomalacic and fibrotic groups, one did not appear to be an intermediate form of the other. The mineralization defect was confined to the osteomalacic group, but was not due to hypocalcemia, since serum calcium was normal and did not differ among the 3 groups. Most of the changes in the mild and fibrotic groups (increases in forming surfa... |
| Databáze: | OpenAIRE |
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