Evaluation of combined anti-PD-1 immunotherapy and radiation therapy in a preclinical mouse model of pneumonitis and fibrosis
| Autor: | David Noyes, Isabel L. Jackson, Theresa A. Boyle, Zeljko Vujaskovic, Kujtim Latifi, Scott J. Antonia, Bradford A. Perez, Derek Nichols, Vladimir Feygelman |
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| Rok vydání: | 2018 |
| Předmět: |
Pulmonary and Respiratory Medicine
Oncology medicine.medical_specialty Chemotherapy Performance status business.industry Short Communication medicine.medical_treatment Anti pd 1 Locally advanced Immunotherapy medicine.disease Radiation therapy Fibrosis Internal medicine Medicine business Pneumonitis |
| Zdroj: | Journal of Thoracic Disease. 10:6254-6260 |
| ISSN: | 2077-6624 2072-1439 |
| DOI: | 10.21037/jtd.2018.10.01 |
| Popis: | Outcomes for patients with inoperable locally advanced non-small cell lung cancer (LA-NSCLC) are poor, with a median survival of about 2 years (1) and a 5-year survival of about 10–15% following diagnosis, even among patients with good performance status at presentation (2). Despite these poor outcomes, conventional radiation therapy (RT) with chemotherapy remains the standard of care. |
| Databáze: | OpenAIRE |
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