Interleukin-13 drives metabolic conditioning of muscle to endurance exercise
| Autor: | Jamie A. Cooper, Frank B. Hu, Chad M. Paton, Wendy S. Garrett, Diogo Fonseca-Pereira, Yae-Huei Liou, Eric A. Ortlund, Kyle A Starost, Danesh H. Sopariwala, Ryan K. Alexander, Kristopher J. Stanya, David Jacobi, Vihang A. Narkar, Mayer M. Chalom, Alexander L. Hyde, Jonathan H. Kim, Jun Li, Sihao Liu, Nelson H. Knudsen, Matthew R. Gangl, Chih-Hao Lee |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Blood Glucose Male STAT3 Transcription Factor medicine.medical_specialty Biology Mitochondrion Cell Line Running Myoblasts 03 medical and health sciences chemistry.chemical_compound Mice 0302 clinical medicine Endurance training Internal medicine Physical Conditioning Animal medicine Animals Humans Receptor STAT3 Muscle Skeletal Beta oxidation Mice Knockout Multidisciplinary Interleukin-13 Glycogen Fatty Acids Adaptation Physiological Interleukin-13 Receptor alpha1 Subunit Mitochondria Muscle Mice Inbred C57BL 030104 developmental biology Endocrinology Mitochondrial biogenesis chemistry Interleukin 13 biology.protein Physical Endurance Female Oxidation-Reduction 030217 neurology & neurosurgery |
| Zdroj: | Science (New York, N.Y.). 368(6490) |
| ISSN: | 1095-9203 |
| Popis: | IL-13 hits the gym Interleukin-13 (IL-13) is a cytokine secreted by T cells, innate lymphoid cells (ILC2s), and granulocytes. It acts as a central mediator in allergy and antihelminth defense with various effects. Knudsen et al. report a distinct role for IL-13 in exercise and metabolism (see the Perspective by Correia and Ruas). Mice subjected to endurance training showed increases in circulating IL-13, which correlated with ILC2 expansion in the muscles. By contrast, exercise-induced increases in muscle fatty acid utilization and mitochondrial biogenesis were erased when mice lacked IL-13. Activation of signaling pathways downstream of the muscle IL-13 receptor was key to this effect. Intramuscular injection of adenoviral IL-13 could recapitulate exercise-induced metabolic reprogramming. This signaling pathway may have evolved to combat the metabolic stresses of parasite infection. Science , this issue p. eaat3987 ; see also p. 470 |
| Databáze: | OpenAIRE |
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