Molecular Mechanisms Underlying PGF2α-induced Hypertrophy of Vascular Smooth Muscle Cells

Autor:	Wentao Liu, Chihiro Yabe-Nishimura, Haiyan Wei, Qingjie Xia, ChunYuan Fan, Masato Katsuyama
Rok vydání:	2010
Předmět:	Transcriptional Activation endocrine system Vascular smooth muscle Receptors Prostaglandin Pharmaceutical Science MADS Domain Proteins Context (language use) Biology Dinoprost Muscle Smooth Vascular Muscle hypertrophy Phosphatidylinositol 3-Kinases Transactivation Downregulation and upregulation Superoxides Animals Humans Receptor Activating Transcription Factor 1 Pharmacology Regulation of gene expression MEF2 Transcription Factors NADPH Oxidases Hypertrophy Up-Regulation Cell biology ErbB Receptors Protein Kinase C-delta src-Family Kinases Gene Expression Regulation Myogenic Regulatory Factors NADPH Oxidase 1 lipids (amino acids peptides and proteins) Signal transduction Signal Transduction
Zdroj:	YAKUGAKU ZASSHI. 130:211-214
ISSN:	1347-5231 0031-6903
DOI:	10.1248/yakushi.130.211
Popis:	The present review focuses primarily on the studies we made in recent years to improve the understanding of the molecular mechanisms of PGF2alpha-induced hypertrophy of Vascular Smooth Muscle Cells (VSMC). In this review, we will summarize the recent findings in the context of the PGF2alpha signaling pathway in three parts: PGF2alpha binding to its receptor, transactivation of EGF receptor, two independent signaling transduction pathways increasing the expression of NOX1 gene.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42ea1248047bac6b573dae78e57107d6 https://doi.org/10.1248/yakushi.130.211 Zobrazit plný text záznamu