Contribution of Cytosine-Containing Cyclobutane Dimers to DNA Damage Produced by Photosensitized Triplet-Triplet Energy Transfer
| Autor: | Aude Wack, Sigrid Andrä, Izabel Bérard, Thierry Douki |
|---|---|
| Přispěvatelé: | Laboratoire Lésions des Acides Nucléiques (LAN), Service de Chimie Inorganique et Biologique (SCIB - UMR E3), Institut Nanosciences et Cryogénie (INAC), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Centre National de la Recherche Scientifique (CNRS)-Institut Nanosciences et Cryogénie (INAC), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Centre National de la Recherche Scientifique (CNRS), Université Grenoble Alpes - UFR Pharmacie (UGA UFRP), Université Grenoble Alpes [2016-2019] (UGA [2016-2019]) |
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Stereochemistry
DNA damage Photochemistry Ultraviolet Rays Pyrimidine dimer 7. Clean energy Catalysis Cyclobutane Nucleobase chemistry.chemical_compound Cytosine Photosensitizer [SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry Molecular Biology/Biochemistry [q-bio.BM] ComputingMilieux_MISCELLANEOUS Photosensitizing Agents Organic Chemistry General Chemistry [SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry Molecular Biology/Biomolecules [q-bio.BM] chemistry Energy Transfer Pyrimidine Dimers Excited state DNA Thymine DNA Damage |
| Zdroj: | Chemistry-A European Journal Chemistry-A European Journal, Wiley-VCH Verlag, 2014, 20 (19), pp.5787-5794. ⟨10.1002/chem.201303905⟩ Chemistry-A European Journal, 2014, 20 (19), pp.5787-5794. ⟨10.1002/chem.201303905⟩ |
| ISSN: | 0947-6539 1521-3765 |
| DOI: | 10.1002/chem.201303905⟩ |
| Popis: | Mutagenic cyclobutane pyrimidine dimers (CPDs) can be induced in DNA through either direct excitation or photosensitized triplet-triplet energy transfer (TTET). In the latter pathway, thymines are expected to receive the excitation energy from the photosensitizer and react with adjacent pyrimidines. By using state-of-the art analytical tools, we provide herein additional information on the formation of cytosine-containing CPDs. We thus determined the yield of all possible CPDs upon TTET in a series of natural DNAs with various base compositions. We show that the distribution of CPDs cannot be explained only by excitation of individual thymines. We propose that the mechanism for TTET involves at least dinucleotides as the minimal targets. The observation of the formation of cytosine-cytosine CPDs also suggests that additional pathways are involved in this photosensitized reaction. |
| Databáze: | OpenAIRE |
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