Comparison of BOLD and CBV using 3D EPI and 3D GRASE for cortical layer functional MRI at 7 T
| Autor: | Tetiana Dadakova, Alexander Beckett, Suhyung Park, Jennifer Townsend, Laurentius Huber, David A. Feinberg |
|---|---|
| Přispěvatelé: | MRI, RS: FPN CN 5 |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
genetic structures
OCULAR DOMINANCE COLUMNS SIGNAL CHANGES Vascular space occupancy Article 030218 nuclear medicine & medical imaging 03 medical and health sciences Imaging Three-Dimensional 0302 clinical medicine Nuclear magnetic resonance Cortex (anatomy) 7 Tesla medicine Biological neural network SPIN-ECHO FMRI Humans Radiology Nuclear Medicine and imaging VISUAL-CORTEX MOTOR CORTEX LAMINAR SPECIFICITY Brain Mapping GRASE QUANTITATIVE ASSESSMENT business.industry WEIGHTED FMRI GRADIENT-ECHO fMRI Brain Human brain cerebral blood volume Magnetic Resonance Imaging Motor task CEREBRAL BLOOD-VOLUME medicine.anatomical_structure Cerebral blood volume nervous system Cerebrovascular Circulation Primary motor cortex business 3d grase vascular space occupancy 030217 neurology & neurosurgery |
| Zdroj: | Magn Reson Med Magnetic Resonance in Medicine, 84(6), 3128-3145. Wiley |
| ISSN: | 0740-3194 |
| DOI: | 10.1002/mrm.28347 |
| Popis: | Purpose: Functional MRI (fMRI) at the mesoscale of cortical layers and columns requires both sensitivity and specificity, the latter of which can be compromised if the imaging method is affected by vascular artifacts, particularly cortical draining veins at the pial surface. Recent studies have shown that cerebral blood volume (CBV) imaging is more specific to the actual laminar locus of neural activity than BOLD imaging using standard gradient‐echo EPI sequences. Gradient and spin‐echo (GRASE) BOLD imaging has also shown greater specificity when compared with standard gradient‐echo EPI BOLD. Here we directly compare CBV and BOLD contrasts in high‐resolution imaging of the primary motor cortex for laminar functional MRI in four combinations of signal labeling, CBV using slice‐selective slab‐inversion vascular space occupancy (VASO) and BOLD, each with 3D gradient‐echo EPI and zoomed 3D‐GRASE image readouts.Methods: Activations were measured using each sequence and contrast combination during a motor task. Activation profiles across cortical depth were measured to assess the sensitivity and specificity (pial bias) of each method.Results: Both CBV imaging using gradient‐echo 3D‐EPI and BOLD imaging using 3D‐GRASE show similar specificity and sensitivity and are therefore useful tools for mesoscopic functional MRI in the human cortex. The combination of GRASE and VASO did not demonstrate high levels of sensitivity, nor show increased specificity.Conclusion: Three‐dimensional EPI with VASO contrast and 3D‐GRASE with BOLD contrast both demonstrate sufficient sensitivity and specificity for laminar functional MRI to be used by neuroscientists in a wide range of investigations of depth‐dependent neural circuitry in the human brain. |
| Databáze: | OpenAIRE |
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