Prognostic Significance of Tumor Volume in Locally Recurrent Nasopharyngeal Carcinoma Treated with Salvage Intensity-Modulated Radiotherapy
| Autor: | Shuai Liu, Ying Guan, Chong Zhao, Shao-Min Huang, Weiwei Xiao, Fei Han, Tai-Xiang Lu, Chengguang Lin, Yunming Tian |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Science medicine.medical_treatment Salvage therapy Metastasis Young Adult medicine Carcinoma Combined Modality Therapy Humans Aged Neoplasm Staging Salvage Therapy Chemotherapy Multidisciplinary Nasopharyngeal Carcinoma business.industry Nasopharyngeal Neoplasms Middle Aged medicine.disease Prognosis Tumor Burden Radiation therapy Treatment Outcome Nasopharyngeal carcinoma Retreatment Medicine Recurrent Nasopharyngeal Carcinoma Female Radiology Radiotherapy Intensity-Modulated Neoplasm Recurrence Local business Research Article Follow-Up Studies |
| Zdroj: | PLoS ONE PLoS ONE, Vol 10, Iss 4, p e0125351 (2015) |
| ISSN: | 1932-6203 |
| Popis: | IntroductionTo evaluate the prognostic value of gross tumor volume (TV) in patients with locally recurrent, nonmetastatic nasopharyngeal carcinoma.MethodsBetween 2001 and 2012, 291 consecutive patients with locally recurrent, nonmetastatic nasopharyngeal carcinoma underwent salvage IMRT were retrospectively reviewed. The correlations between TV and recurrent T classification were analyzed. Survival analyses were performed. Receiver operating characteristic (ROC) curves were calculated to identify cut-off point of TV. The Akaike information criterion and Harrell's concordance index (c-index) were utilized to test the prognostic value.ResultsThe median TV significantly increased with advancing recurrent T classification (PConclusionsOur data suggests TV is a significant prognostic factor for predicting the distant metastasis, overall survival and toxicity-related death of patients with locally recurrent, nonmetastatic nasopharyngeal carcinoma after salvage IMRT. TV should be considered when designing personalized salvage treatments for these patients. For patients with bulky local recurrent tumor, radiation may need to be de-emphasized in favor of systemic treatment or best supportive care. |
| Databáze: | OpenAIRE |
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