25-Hydroxyvitamin D reference percentiles and the role of their determinants among European children and adolescents

Autor: Luis Moreno, Gabriele Eiben, Wolfgang Ahrens, Timm Intemann, Dénes Molnár, Anna Floegel, Michael Tornaritis, Maike Wolters, Toomas Veidebaum, Paola Russo, Stefaan De Henauw
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Zaguán. Repositorio Digital de la Universidad de Zaragoza
instname
EUROPEAN JOURNAL OF CLINICAL NUTRITION
European journal of nutrition
(2021). doi:10.1038/s41430-021-00985-4
info:cnr-pdr/source/autori:Wolters M, Intemann T, Russo P, Moreno LA, Molnár D, Veidebaum T, Tornaritis M, De Henauw S, Eiben G, Ahrens W, Floegel A on behalf of the IDEFICS and I.Family consortia/titolo:25-Hydroxyvitamin D reference percentiles and the role of their determinants among European children and adolescents./doi:10.1038%2Fs41430-021-00985-4/rivista:European journal of nutrition (Print)/anno:2021/pagina_da:/pagina_a:/intervallo_pagine:/volume
European journal of clinical nutrition, 76(4):564-573
ISSN: 0954-3007
1476-5640
DOI: 10.1038/s41430-021-00985-4
Popis: Background/objectives To provide age- and sex-specific percentile curves of serum 25-hydroxyvitamin D (25(OH)D) by determinants from 3- Subjects/methods Serum samples were collected from children of eight European countries participating in the multicenter IDEFICS/I.Family cohort studies. Serum 25(OH)D concentrations were analysed in a central lab by a chemiluminescence assay and the values from 2171 children (N = 3606 measurements) were used to estimate percentile curves using the generalized additive model for location, scale and shape. The association of 25(OH)D with time spent outdoors was investigated considering sex, age, country, parental education, BMI z score, UV radiation, and dietary vitamin D in regressions models. Results The age- and sex-specific 5th and 95th percentiles of 25(OH)D ranged from 16.5 to 73.3 and 20.8 to 79.3 nmol/l in girls and boys, respectively. A total of 63% had deficient (z score and age. The odds ratio (OR) for a non-deficient 25(OH)D status (reference category: deficient status) by one additional hour spent outdoors was 1.21, 95% CI [1.12–1.31], i.e., children who spent one more hour per day outdoors than other children had a 21% higher chance of a non-deficient than a deficient status. Conclusion A majority of children suffer from deficient 25(OH)D. UV radiation, outdoor time, and dietary vitamin D are important determinants of 25(OH)D.
Databáze: OpenAIRE
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