COVID-19 Severity and COVID-19-Associated Deaths Among Hospitalized Patients with HIV Infection - Zambia, March-December 2020
| Autor: | Nyuma Mbewe, Simon Agolory, Kennedy Malama, Davies Kampamba, Jonas Z Hines, Katongo H Mutengo, Aggrey Mweemba, Khozya Zyambo, Sombo Fwoloshi, Robert Chirwa, Suilanji Sivile, Lloyd Mulenga, Peter Minchella, Mary Adetinuke Boyd, Megumi Itoh, Duncan Chanda, Kalongo Hamusonde, Kotey I Nikoi, Lameck Chirwa, Mpanji Siwingwa |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Male Pediatrics medicine.medical_specialty Health (social science) Coronavirus disease 2019 (COVID-19) Adolescent Epidemiology Hospitalized patients Health Toxicology and Mutagenesis Human immunodeficiency virus (HIV) MEDLINE Zambia HIV Infections medicine.disease_cause 01 natural sciences Severity of Illness Index 03 medical and health sciences Young Adult 0302 clinical medicine Health Information Management Severity of illness medicine Humans 030212 general & internal medicine Viral suppression Full Report 0101 mathematics Young adult business.industry 010102 general mathematics COVID-19 General Medicine Middle Aged Hospitalization Treatment Outcome Female business Viral load |
| Zdroj: | Morbidity and Mortality Weekly Report |
| ISSN: | 1545-861X |
| Popis: | The effect of HIV infection on COVID-19 outcomes is unclear. Studies in South Africa (1) and the United Kingdom (2) found an independent association between HIV infection and COVID-19 mortality; however, other studies have not found an association between poor COVID-19 outcomes and either HIV status among hospitalized patients (3-5) or HIV-associated factors such as CD4 count, viral load, or type of antiretroviral therapy (ART) (6). The effect of HIV infection on COVID-19 outcomes remains an urgent question in sub-Saharan Africa, where many countries are experiencing dual HIV and COVID-19 epidemics, and capacity to treat severe COVID-19 is limited. Using data from patients with probable or confirmed COVID-19 admitted to specialized treatment centers during March-December 2020 in Zambia, the Zambian Ministry of Health and CDC assessed the relationship between HIV infection and severe COVID-19 and COVID-19-associated death. Among 443 patients included in the study, 122 (28%) were HIV-positive, and of these, 91 (89%) were receiving ART at the time of hospitalization. HIV status alone was not significantly associated with severe COVID-19 at admission or during hospitalization or with COVID-19-associated death. However, among HIV-positive persons, those with severe HIV disease were more likely to develop severe COVID-19 and were at increased risk for COVID-19-associated death. Ensuring that persons maintain HIV disease control, including maintaining ART continuity and adherence, achieving viral suppression, and addressing and managing underlying medical conditions, could help reduce COVID-19-associated morbidity and mortality in sub-Saharan Africa. |
| Databáze: | OpenAIRE |
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