Migratory Dendritic Cells, Group 1 Innate Lymphoid Cells, and Inflammatory Monocytes Collaborate to Recruit NK Cells to the Virus-Infected Lymph Node
| Autor: | Avital Lev, Colby Stotesbury, Luis J. Sigal, Daniel Rubio, Ren-Huan Xu, Eric B. Wong, Min Fang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Male Receptors CXCR3 Ectromelia virus chemical and pharmacologic phenomena Ligands Chemokine CXCL9 General Biochemistry Genetics and Molecular Biology Virus Monocytes Article 03 medical and health sciences 0302 clinical medicine Cell Movement medicine Animals Endothelium Lymphocytes Lymph node lcsh:QH301-705.5 Inflammation biology integumentary system Innate lymphoid cell TLR9 DNA virus hemic and immune systems Dendritic Cells biology.organism_classification NKG2D Immunity Innate Killer Cells Natural Mice Inbred C57BL 030104 developmental biology medicine.anatomical_structure lcsh:Biology (General) NK Cell Lectin-Like Receptor Subfamily K Toll-Like Receptor 9 Immunology Myeloid Differentiation Factor 88 Female Lymph Interferons Lymph Nodes Stromal Cells 030215 immunology |
| Zdroj: | Cell Reports, Vol 24, Iss 1, Pp 142-154 (2018) |
| ISSN: | 2211-1247 |
| Popis: | Summary: Circulating natural killer (NK) cells help protect the host from lympho-hematogenous acute viral diseases by rapidly entering draining lymph nodes (dLNs) to curb virus dissemination. Here, we identify a highly choreographed mechanism underlying this process. Using footpad infection with ectromelia virus, a pathogenic DNA virus of mice, we show that TLR9/MyD88 sensing induces NKG2D ligands in virus-infected, skin-derived migratory dendritic cells (mDCs) to induce production of IFN-γ by classical NK cells and other types of group 1 innate lymphoid cells (ILCs) already in dLNs, via NKG2D. Uninfected inflammatory monocytes, also recruited to dLNs by mDCs in a TLR9/MyD88-dependent manner, respond to IFN-γ by secreting CXCL9 for optimal CXCR3-dependent recruitment of circulating NK cells. This work unveils a TLR9/MyD88-dependent mechanism whereby in dLNs, three cell types—mDCs, group 1 ILCs (mostly NK cells), and inflammatory monocytes—coordinate the recruitment of protective circulating NK cells to dLNs. : Wong et al. show that infected migratory dendritic cells (mDCs) in draining lymph nodes (dLNs) upregulate NKG2D ligands through TLR9/MyD88. This results in NKG2D-dependent IFN-γ production by group 1 innate lymphoid cells, mostly NK cells. IFN-γ induces CXCL9 in uninfected inflammatory monocytes, leading to the recruitment of protective NK cells to dLNs. Keywords: viral infection, mouse, poxvirus, ectromelia virus, NK cells, dendritic cells, monocytes, dendritic cells, innate lymphoid cells, interferon |
| Databáze: | OpenAIRE |
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