Sex-Specific Effects of Chronic Administration of Relaxin-3 on Food Intake, Body Weight and the Hypothalamic-Pituitary-Gonadal Axis in Rats
| Autor: | C. de Ávila, Juliane Calvez, Elena Timofeeva, Geneviève Guèvremont |
|---|---|
| Přispěvatelé: | Institut Universitaire de Cardiologie et de Pneumologie de Québec (IUCPQ), Université Laval [Québec] (ULaval), Natural Sciences and Engineering Research Council of Canada (NSERC), Canadian Institutes of Health Research (CIHR) |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Male endocrine system medicine.medical_specialty food intake relaxin-3 [SDV]Life Sciences [q-bio] Endocrinology Diabetes and Metabolism Period (gene) Hypothalamus Hypothalamic–pituitary–gonadal axis Estrous Cycle Nerve Tissue Proteins White adipose tissue Body weight sex hormones Feed conversion ratio Rats Sprague-Dawley 03 medical and health sciences Cellular and Molecular Neuroscience Eating 0302 clinical medicine Endocrinology Internal medicine Neural Pathways Medicine Animals Gonads 2. Zero hunger Estrous cycle Sex Characteristics Endocrine and Autonomic Systems business.industry Body Weight Relaxin Preoptic Area sex-specific 030104 developmental biology Pituitary Gland Female business Relaxin-3 030217 neurology & neurosurgery Hormone |
| Zdroj: | Journal of Neuroendocrinology Journal of Neuroendocrinology, Wiley, 2016, 28 (12), ⟨10.1111/jne.12439⟩ |
| ISSN: | 1365-2826 0953-8194 |
| DOI: | 10.1111/jne.12439⟩ |
| Popis: | This study examined the effects of chronic central administration of relaxin-3 (RLN3) on food intake, body weight and fat mass in intact and sterilized male and female rats as well as on the hypothalamo-pituitary-gonadal (HPG) axis activity in intact male and female rats that received intracerebroventricular (icv) infusions of RLN3 (400 pmol/day) or vehicle during a 14-day period. The intact RLN3-injected rats displayed higher body weight than the vehicle-treated groups, and this increase was statistically significantly stronger in the female rats compared to the male rats. In addition, feed efficiency and gonadal white adipose tissue weight were higher in the female RLN3-injected rats. Chronic icv administration of RLN3 activated the HPG axis in the intact male rats whereas inhibition of the HPG axis was observed in the intact female rats. RLN3 significantly increased the plasma levels of luteinizing hormone and follicular stimulating hormone in the male rats but not in female rats. Conversely, hypothalamic expression of gonadotropin-releasing hormone mRNA was decreased by RLN3 in the female rats but not in the male rats. In addition, the plasma levels of estradiol were significantly decreased by RLN3 administration in the female rats. Consequently, the intact RLN3-injected female rats failed to display phasic inhibition of eating during estrus. Sex-specific effects of RLN3 on food intake and body weight were also observed in ovariectomized female and orchidectomized male rats suggesting that the sex-specific effects of RLN3 on energy metabolism are independent on the differential effects of RLN3 on HPG axis activity in male and female rats. This article is protected by copyright. All rights reserved. |
| Databáze: | OpenAIRE |
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