Dielectrophoresis-Based Integrated Lab-on-Chip for Nano and Micro-Particles Manipulation and Capacitive Detection
| Autor: | Mohamed Amine, Miled, Geneviève, Massicotte, Mohamad, Sawan |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Engineering
Capacitive sensing Biomedical Engineering Hardware_PERFORMANCEANDRELIABILITY Electric Capacitance law.invention Frequency divider law Microsystem Hardware_INTEGRATEDCIRCUITS Electronic engineering Computer Simulation System on a chip Electrical and Electronic Engineering Electrodes Dynamic range business.industry Oxides Signal Processing Computer-Assisted Microfluidic Analytical Techniques Dielectrophoresis Lab-on-a-chip Chip Microspheres Semiconductors Metals Microtechnology Nanoparticles business Analog-Digital Conversion |
| Zdroj: | IEEE Transactions on Biomedical Circuits and Systems. 6:120-132 |
| ISSN: | 1940-9990 1932-4545 |
| DOI: | 10.1109/tbcas.2012.2185844 |
| Popis: | We present in this paper a new Lab-on-Chip (LoC) architecture for dielectrophoresis-based cell manipulation, detection, and capacitive measurement. The proposed LoC is built around a CMOS full-custom chip and a microfluidic structure. The CMOS chip is used to deliver all parameters required to control the dielectrophoresis (DEP) features such as frequency, phase, and amplitude of signals spread on in-channel electrodes of the LoC. It is integrated to the LoC and experimental results are related to micro and nano particles manipulation and detection in a microfluidic platform. The proposed microsystem includes an on-chip 27-bit frequency divider, a digital phase controller with a 3.6° phase shift resolution and a 2.5 V dynamic range. The sensing module is composed of a 3 × 3 capacitive sensor array with 10 fF per mV sensitivity, and a dynamic range of 1.5 V. The obtained results show an efficient nano and micro-particles (PC05N, PA04N and PS03N) separation based on frequency segregation with low voltages less than 1.7 V and a fully integrated and reconfigurable system. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|