Seroprevalence of hepatitis B in two period birth cohorts of Bolivian children: effect of universal vaccination
| Autor: | Sandra Lucia Montaño Rodríguez, Cristina Masuet-Aumatell, Marta Banqué-Navarro, María del Rosario Dávalos-Gamboa, Josep Maria Ramon-Torrell, Aurora Casanova-Rituerto |
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| Rok vydání: | 2013 |
| Předmět: |
Male
Bolivia medicine.medical_specialty Hepatitis B vaccine Adolescent Immunization Secondary medicine.disease_cause Immunoglobulin G Cohort Studies Seroepidemiologic Studies Internal medicine Humans Medicine Seroprevalence Hepatitis B Vaccines Hepatitis B Antibodies Child Hepatitis B virus biology business.industry Public Health Environmental and Occupational Health virus diseases General Medicine Hepatitis B medicine.disease Antibodies Anti-Idiotypic Vaccination Cross-Sectional Studies Infectious Diseases Immunization Child Preschool Immunology Cohort biology.protein Female Parasitology business |
| Zdroj: | Transactions of The Royal Society of Tropical Medicine and Hygiene. 107:578-583 |
| ISSN: | 1878-3503 0035-9203 |
| DOI: | 10.1093/trstmh/trt057 |
| Popis: | Background Since 2000 universal routine immunization against the hepatitis B virus (HBV) was implemented in Bolivia. This study aimed to assess the seroprevalence of markers against HBV in two different birth cohorts (pre-universal vaccine cohort and post-universal vaccine cohort) from Cochabamba, Bolivia. Methods We performed a school-based seroepidemiological survey (n = 424) of HBV in 2010 in the Cochabamba region. An ELISA test was used to measure antibodies to the hepatitis B surface antigen (anti-HBs IgG) and to the hepatitis B core antigen (anti-HBc IgG). Results The prevalence of anti-HBs IgG in the pre-universal vaccine cohort was 5.8% (95% CI: 3.3-8.3%); it was higher in boys (9.1%), and those living in suburbs (9.7%). The anti-HBs IgG prevalence among post-universal vaccine cohort was 37.9% (95% CI: 28.5-48.1%), and was higher in children who spoke Quechua at home (51.0%), those living in suburbs (53.9%), and those born in 2005 (72.7%). Neither cohort showed differences relating to parental education. The prevalence of anti-HBc IgG was 1.1% among post-universal vaccine cohort and 1.2% among pre-universal vaccine cohort (p > 0.05). Conclusions This study identified a persistent low seroprevalence of hepatitis B infection in spite of a decade of universal immunization, and low long-term humoral immunity against HBV infection in vaccinated children in Cochabamba. |
| Databáze: | OpenAIRE |
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