Risk factors and impact of recurrent lupus nephritis in patients with systemic lupus erythematosus undergoing renal transplantation: data from a single US institution
| Autor: | Scott A. Kendrick, Jigna Liu, Clifton E. Kew, William J. Cook, Graciela S. Alarcón, W. Kendrick, Elizabeth L. Perkins, Bruce A. Julian, Paula I. Burgos, Guillermo J. Pons-Estel |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
Graft Rejection Male medicine.medical_specialty Pathology Adolescent Immunology Lupus nephritis Article Young Adult Sex Factors Rheumatology Recurrence Risk Factors Internal medicine medicine Immunology and Allergy Humans Lupus Erythematosus Systemic Pharmacology (medical) Risk factor Survival analysis Kidney transplantation Aged Proportional Hazards Models Retrospective Studies Aged 80 and over Lupus erythematosus business.industry Hazard ratio Middle Aged medicine.disease Kidney Transplantation Lupus Nephritis Survival Analysis United States Transplantation Black or African American Female business Kidney disease |
| Zdroj: | Arthritis and rheumatism. 60(9) |
| ISSN: | 0004-3591 |
| Popis: | Objective To determine the risk factors for recurrent lupus nephritis, allograft loss, and survival among patients with systemic lupus erythematosus (SLE) undergoing kidney transplantation. Methods The archival records of all kidney transplant recipients with a prior diagnosis of SLE (according to the American College of Rheumatology criteria) from June 1977 to June 2007 were reviewed. Patients who had died or lost the allograft within 90 days of engraftment were excluded. Time-to-event data were examined by univariable and multivariable Cox proportional hazards regression analyses. Results Two hundred twenty of nearly 7,000 renal transplantations were performed in 202 SLE patients during the 30-year interval. Of the 177 patients who met the criteria for study entry, the majority were women (80%) and African American (65%), the mean age was 35.6 years, and the mean disease duration was 11.2 years. Recurrent lupus nephritis was noted in 20 patients (11%), allograft loss in 69 patients (39%), and death in 36 patients (20%). African American ethnicity was found to be associated with a shorter time-to-event for recurrent lupus nephritis (hazard ratio [HR] 4.63, 95% confidence interval [95% CI] 1.29–16.65) and death (HR 2.47, 95% CI 0.91–6.71), although, with the latter, the association was not statistically significant. Recurrent lupus nephritis and chronic rejection of the kidney transplant were found to be risk factors for allograft loss (HR 2.48, 95% CI 1.09–5.60 and HR 2.72, 95% CI 1.55–4.78, respectively). In patients with recurrent lupus nephritis, the lesion in the engrafted kidney was predominantly mesangial, compared with a predominance of proliferative or membranous lesions in the native kidneys. Conclusion African American ethnicity was independently associated with recurrent lupus nephritis. Allograft loss was associated with chronic transplant rejection and recurrence of lupus nephritis. Recurrent lupus nephritis is infrequent and relatively benign, without influence on a patient's survival. |
| Databáze: | OpenAIRE |
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