Autocrine signaling by an Aplysia neurotrophin forms a presynaptic positive feedback loop
| Autor: | Russell E. Nicholls, Robert D. Hawkins, Iksung Jin, Hiroshi Udo, Huixiang Zhu, Eric R. Kandel |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Serotonin Sensory Receptor Cells Long-Term Potentiation Presynaptic Terminals Synapse 03 medical and health sciences 0302 clinical medicine Postsynaptic potential Aplysia medicine Animals Nerve Growth Factors Autocrine signalling Positive feedback Motor Neurons Serotonin Plasma Membrane Transport Proteins Neuronal Plasticity Multidisciplinary biology Chemistry Excitatory Postsynaptic Potentials Receptor Protein-Tyrosine Kinases biology.organism_classification Cyclic AMP-Dependent Protein Kinases Autocrine Communication 030104 developmental biology medicine.anatomical_structure PNAS Plus Synapses Synaptic plasticity biology.protein Neuron Neuroscience 030217 neurology & neurosurgery Signal Transduction Neurotrophin |
| Zdroj: | Proceedings of the National Academy of Sciences. 115 |
| ISSN: | 1091-6490 0027-8424 |
| DOI: | 10.1073/pnas.1810649115 |
| Popis: | Whereas short-term plasticity is often initiated on one side of the synapse, long-term plasticity involves coordinated changes on both sides, implying extracellular signaling. We have investigated the possible signaling role of an Aplysia neurotrophin (ApNT) in facilitation induced by serotonin (5HT) at sensory-to-motor neuron synapses in culture. ApNT is an ortholog of mammalian BDNF, which has been reported to act as either an anterograde, retrograde, or autocrine signal, so that its pre- and postsynaptic sources and targets remain unclear. We now report that ApNT acts as a presynaptic autocrine signal that forms part of a positive feedback loop with ApTrk and PKA. That loop stimulates spontaneous transmitter release, which recruits postsynaptic mechanisms, and presynaptic protein synthesis during the transition from short- to intermediate-term facilitation and may also initiate gene regulation to trigger the transition to long-term facilitation. These results suggest that a presynaptic ApNT feedback loop plays several key roles during consolidation of learning-related synaptic plasticity. |
| Databáze: | OpenAIRE |
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