Preperitoneal balloon tamponade and resuscitative endovascular balloon occlusion of the aorta: Alternatives to open packing for pelvic fracture-associated hemorrhage
| Autor: | Sara R Hegge, Matthew J. Martin, Rowan R. Sheldon, Matthew J. Eckert, Kyle K. Sokol, George E. Black, Jessica B. Weiss, Morgan R. Barron, Dominic M Forte, Woo S Do |
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| Rok vydání: | 2019 |
| Předmět: |
Male
Mean arterial pressure Balloon tamponade Swine medicine.medical_treatment Resuscitation Hemodynamics Hemorrhage Hematocrit Shock Hemorrhagic Critical Care and Intensive Care Medicine Balloon 03 medical and health sciences Fractures Bone 0302 clinical medicine medicine.artery medicine Animals Pelvic Bones Aorta medicine.diagnostic_test business.industry 030208 emergency & critical care medicine Bleed Balloon Occlusion Disease Models Animal Shock (circulatory) Anesthesia Surgery medicine.symptom business |
| Zdroj: | The journal of trauma and acute care surgery. 87(1) |
| ISSN: | 2163-0763 |
| Popis: | BACKGROUND The objective of this study was to compare the efficacy of preperitoneal balloon tamponade (PPB), resuscitative endovascular balloon occlusion of the orta (REBOA), and open preperitoneal packing (OP) in a realistic animal model of pelvic fracture-associated hemorrhage. METHODS Thirty-nine swine underwent creation of open-book pelvic fracture and iliac vascular injury. Animals were randomized to no intervention (n = 7), OP (n = 10), PPB (n = 9), zone 1 REBOA (n = 7), and zone 3 REBOA (n = 6) at a mean arterial pressure less than 40 mm Hg from uncontrolled hemorrhage. Primary outcome was survival at 1 hour. Secondary outcomes included survival in the immediate 10 m following intervention reversal, peak preperitoneal pressure (PP), blood loss, bleed rate, and peak lactate. RESULTS Prior to injury, no difference was measured between groups for weight, hemodynamics, lactate, and hematocrit (all p = NS). The injury was uniformly lethal without intervention, with survival time (mean) of 5 m, peak PP of 14 mm Hg, blood loss of 960 g, bleed rate of 450 g/m, and peak lactate of 2.6 mmol/L. Survival time (m) was extended to 44 with OP, 60 with PPB, and 60 with REBOA (p < 0.01). Peak PP (mm Hg) was 19 with OP, 23 with PPB, 10 with zone 1 REBOA, and 6 with zone 3 REBOA (p < 0.05). Blood loss (g) was 850 with OP, 930 with PPB, 610 with zone 1 REBOA, and 370 with zone 3 REBOA (p < 0.01). Peak lactate (mmol/L) was 3.3 with OP, 4.3 with PPB, 13.4 with zone 1 REBOA, and 5.3 with zone 3 REBOA (p < 0.01). Only 33% of zone 1 REBOA animals survived the initial 10 m after balloon deflation, compared to 60% for OP, 67% for PPB, and 100% for zone 3 REBOA (p < 0.01). CONCLUSION Preperitoneal balloon tamponade and zone 3 REBOA are effective alternatives to OP in this animal model of lethal pelvic fracture-associated hemorrhage. Zone 1 REBOA extends survival time but with high mortality upon reversal. |
| Databáze: | OpenAIRE |
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