Sarcoid-like reaction in cases treated by checkpoint inhibitors
| Autor: | Semra Paydas |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Cancer Research
medicine.medical_specialty Hematology Withholding Treatment Sarcoidosis business.industry Immune checkpoint inhibitors Disease progression General Medicine Antibodies Monoclonal Humanized medicine.disease Dermatology 03 medical and health sciences 0302 clinical medicine Oncology Neoplasms 030220 oncology & carcinogenesis Internal medicine medicine Humans Granulomatous disorder business Immune Checkpoint Inhibitors |
| Zdroj: | Medical Oncology. 38 |
| ISSN: | 1559-131X 1357-0560 |
| DOI: | 10.1007/s12032-021-01477-y |
| Popis: | Sarcoidosis is a multisystem granulomatous disorder characterized by helper T cell inflammation. Sarcoid-like reaction (SLR) is a well-defined entity and may be related with several malignant disorders and/or their therapies. SLR has been reported more than 20 years ago and in recent years in cases treated by checkpoint inhibitors (CPIs). Better outcome has been reported in cases developing granulomatous reaction and/or SLRs during CPI treatments. However, these lesions clinically may be thought as disease progression and may cause to stop treatment or alterations. These therapeutic manipulations may be harmful for the patients. Clinicians should be aware of SLRs in cases treated by CPIs and tissues must be sampled and reviewed by an experienced pathologist to avoid misdiagnosis and also unnecessary CPI treatment cessations. Significance Statement Clinicians should be aware of sarcoid-like reactions in cases treated by checkpoint inhibitors and tissues must be sampled and reviewed by an experienced pathologist to avoid misdiagnosis and CPI treatment stops. |
| Databáze: | OpenAIRE |
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