POLYMORPHIC VARIANTS OF THE GENE OF INTERFERON LAMBDA 3 AND FEATURES OF IMMUNE RESPONSE IN CHILDREN WITH CHRONIC VIRAL HEPATITIS C
| Autor: | T. B. Sentsova, I. A. Matinyan, I. V. Vorozhko, L. I. Ilyenko, T. V. Strokova, O. O. Chernyak |
|---|---|
| Jazyk: | ruština |
| Rok vydání: | 2017 |
| Předmět: |
gene polymorphism
genotype rs12979860 Biology Pediatrics RJ1-570 Proinflammatory cytokine chemistry.chemical_compound Immune system children Immunity Pegylated interferon Genotype medicine Allele interferon-λ 3 Ribavirin virus diseases rs8099917 Virology immunity chemistry Pediatrics Perinatology and Child Health Immunology Gene polymorphism medicine.drug |
| Zdroj: | Rossijskij Vestnik Perinatologii i Pediatrii, Vol 62, Iss 4, Pp 32-36 (2017) |
| ISSN: | 2500-2228 1027-4065 |
| Popis: | To study the immune manifestations of the interferon-lambda 3 genepolymorphism in chronic viral hepatitis C, 110 Russian children (54 girls and 56 boys) with chronic HCV infection aged from 3 to 17 years were examined. All children were on combined therapy (pegylated interferon + ribavirin). It was found that among the studied polymorphic variants of the IFN-λ 3 gene in children with chronic HCV infection, T allele of the marker rs12979860 is associated with infection and chronization of HCV. The T/T rs12979860 genotype of the IFN-λ3 gene is unfavorable for the course of chronic HCV infection due to low levels of activated T-lymphocytes, intactness of the proinflammatory cytokines TNF-α, IL-6, IL-1α, and interferon-γ inducible protein IP-10. The revealed relation of the polymorphic variants of C/C + C/T locus rs12979860 of INF-λ3 gene with the expression of activated T-lymphocytes discloses the protective nature of these genotypes to the development of chronic HCV infection in children. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|