Supplementary Tables 1-4 from Phase I Study of Pazopanib in Patients with Advanced Solid Tumors and Hepatic Dysfunction: A National Cancer Institute Organ Dysfunction Working Group Study

Autor: Edward M. Newman, S. Percy Ivy, S. Cecilia Lau, Leena Gandhi, Chandra P. Belani, Daniel L. Mulkerin, Afshin Dowlati, Michelle A. Rudek, Patricia LoRusso, John Sarantopoulos, Bert H. O'Neil, Anne L. Hamilton, R. Donald Harvey, Shivaani Kummar, Heinz-Josef Lenz, Lone H. Ottesen, A. Benjamin Suttle, Jeffrey A. Longmate, Timothy W. Synold, Vincent Chung, Stephen I. Shibata
Rok vydání: 2023
DOI: 10.1158/1078-0432.22452693.v1
Popis: PDF - 90K, Supplemental Table 1: Most Frequently Reported Adverse Events at Least Possibly Related to Pazopanib Supplemental Table 2: Steady-State Pazopanib Metabolite Pharmacokinetics Measured in All Patients at Week 3 (medians and ranges) Supplemental Table 3: Ratio of Metabolite AUC(0-6) to Pazopanib AUC(0-6) Measured at Steady-State in All Patients at Week 3 (medians and ranges) Supplemental Table 4: First-dose Pazopanib Metabolite Pharmacokinetics in Expanded Cohorts and the Maximum Tolerated Dose (medians and ranges)
Databáze: OpenAIRE