Long-Term Near-Infrared Signal Tracking of the Therapeutic Changes of Glioblastoma Cells in Brain Tissue with Ultrasound-Guided Persistent Luminescent Nanocomposites
| Autor: | Ru-Shi Liu, Chiao-Ling Cheng, Michael Hsiao, Sheng-Jan Feng, Ming-Hsien Chan |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Materials science
Cell Survival Infrared Rays Surface Properties Ultrasonic Therapy 02 engineering and technology Brain tissue Nanocomposites 03 medical and health sciences Cell Line Tumor Temozolomide medicine Animals Humans General Materials Science Particle Size Antineoplastic Agents Alkylating 030304 developmental biology 0303 health sciences Molecular Structure Brain Neoplasms business.industry Ultrasound Neoplasms Experimental 021001 nanoscience & nanotechnology medicine.disease Ultrasound guided Ultrasonic Waves nervous system Physical Barrier Blood-Brain Barrier Signal tracking Drug delivery cardiovascular system Glioblastoma 0210 nano-technology business Biomedical engineering |
| Zdroj: | ACS Applied Materials & Interfaces. 13:6099-6108 |
| ISSN: | 1944-8252 1944-8244 |
| DOI: | 10.1021/acsami.0c22489 |
| Popis: | The blood-brain barrier (BBB) is a physical barrier that selectively prevents certain substances from entering the brain through the blood. The BBB protects the brain from germs and causes difficulty in intracranial treatment. The chemotherapy drug temozolomide (TMZ), embedded in nanobubbles (NBs) and combined with persistent luminescent nanoparticles (PLNs), has been used to treat glioblastoma (GBM) effectively through image tracking. Through ultrasound induction, NBs produce cavitation that temporarily opens the BBB. Additionally, the PLNs release near-infrared emission and afterglow, which can penetrate deep tissues and improve the signal-to-noise ratio of bioimages. In this work, the nanosystem crossed the BBB for drug delivery and image tracking over time, allowing the enhancement of the drug's therapeutic effect on GBM. We hope that this nanosystem can be applied to the treatment of different brain diseases by embedding different drugs in NBs. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|