How Increased Nodal Metastasis and Recurrence in Cribriform Adenocarcinoma Relate to Polymorphous Adenocarcinoma and Survival: A Systematic Review
| Autor: | Stacey M. Gargano, Madalina Tuluc, Elliot Cherkas, James C. Gates, Dennis Kraus |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Oncology
medicine.medical_specialty endocrine system diseases Disease Adenocarcinoma Medical Oncology 03 medical and health sciences 0302 clinical medicine Transforming Growth Factor beta Tongue Histologic grade Internal medicine medicine Humans business.industry Nodal metastasis Incidence (epidemiology) 030206 dentistry Salivary Gland Neoplasms medicine.disease Aggression medicine.anatomical_structure Otorhinolaryngology 030220 oncology & carcinogenesis Cohort Cribriform Female Surgery Neoplasm Recurrence Local Oral Surgery business |
| Zdroj: | Journal of Oral and Maxillofacial Surgery. 79:1970-1976 |
| ISSN: | 0278-2391 |
| Popis: | Background Recently, histologic grade was removed from salivary tumor nomenclature by the WHO to include disease of higher grade. One such entity, cribriform adenocarcinoma (CAC), is an aggressive group of polymorphous adenocarcinoma (PAC), with frequent nodal metastasis and locoregional recurrence. We aim to examine the biologic behavior of this disease as compared with the PAC general cohort inclusive of all subtypes. Methods A systematic review of the literature on polymorphous adenocarcinoma and cribriform adenocarcinoma was completed. A descriptive analysis was performed for the following predictor variables: nodal and distant metastasis, in addition to recurrence. The outcome variables, disease free recurrence, and disease specific survival, where plotted using Kaplan-Meier curves. Results PAC and CAC both show median age of diagnosis in the sixth decade of life and a female predominance. CAC occurs most frequently in the tongue and PAC in the palate. The 2 groups show a similar biologic behavior in regards to incidence of distant metastasis (4.1 vs 5.5%), recurrence (12.5 vs 17.8%), and death from disease (3 vs 2.7%). However, there was an increased incidence of nodal metastasis in CAC (53%) as compared with that in PAC of all subtypes (14%). Conclusions CAC exhibits more aggressive biologic behavior as compared with the PAC cohort. Although CAC is not an officially recognized entity, these tumors likely comprise a significant portion of the cases of PAC with poor outcomes and are deserving of attention and consideration for escalation in oncologic treatment. |
| Databáze: | OpenAIRE |
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