Intraocular Pressure After a Two-Week Washout Following Long-Term Timolol or Levobunolol
| Autor: | Dong H. Shin, Byung Hee Ahn, Young J. Hong, Beverly McCarty |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Adult
Male medicine.medical_specialty Intraocular pressure genetic structures Administration Topical Eye disease Adrenergic beta-Antagonists Levobunolol Ocular hypertension Glaucoma Timolol Tonometry Ocular Ophthalmology medicine Humans Pharmacology (medical) Intraocular Pressure Aged Retrospective Studies Pharmacology Eye Color business.industry Washout Middle Aged medicine.disease eye diseases Anesthesia Female Ocular Hypertension sense organs Ophthalmic Solutions business Glaucoma Open-Angle medicine.drug Blue irides |
| Zdroj: | Journal of Ocular Pharmacology and Therapeutics. 11:107-112 |
| ISSN: | 1557-7732 1080-7683 |
| DOI: | 10.1089/jop.1995.11.107 |
| Popis: | The effect on intraocular pressure (IOP) of a 2-week washout following long-term ocular therapy with topical levobunolol or timolol for an average period of 30 months was investigated in 20 patients (11 whites and 9 blacks) with early primary open-angle glaucoma or ocular hypertensive glaucoma suspect status. The 2-week washout IOP was significantly lower than the pretreatment baseline IOP in the total 20 patients (P < 0.001), and in the 9 black patients (P = 0.004), but not in the 11 white patients (P = 0.065). However, the washout IOP was found to be significantly lower than the baseline IOP in the 5 whites with brown irides (P = 0.024) but not in the 6 whites with blue irides (P = 0.574). Thus, the 2-week washout following long-term ocular therapy with a topical beta 1-, beta 2-blocker appears insufficient to restore IOP to the pretreatment baseline level in blacks and in the whites with brown irides, whereas it may be adequate in the majority of the whites with blue irides. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|