Evaluation of the swelling behaviour of iota-carrageenan in monolithic matrix tablets
| Autor: | Klára Pintye-Hódi, András Kelemen, Gyula Buchholcz, Tamás Sovány |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Chemistry
Clinical Biochemistry Analytical chemistry Pharmaceutical Science Hydrogen-Ion Concentration Carrageenan Analytical Chemistry Matrix (chemical analysis) Excipients chemistry.chemical_compound Drug Liberation Drug Delivery Systems Delayed-Action Preparations Drug Discovery medicine Pressure Time curve Swelling medicine.symptom Composite material Iota-Carrageenan Spectroscopy Software Tablets |
| Zdroj: | Journal of pharmaceutical and biomedical analysis. 112 |
| ISSN: | 1873-264X |
| Popis: | The swelling properties of monolithic matrix tablets containing iota-carrageenan were studied at different pH values, with measurements of the swelling force and characterization of the profile of the swelling curve. The swelling force meter was linked to a PC by an RS232 cable and the measured data were evaluated with self-developed software. The monitor displayed the swelling force vs. time curve with the important parameters, which could be fitted with an Analysis menu. In the case of iota-carrageenan matrix tablets, it was concluded that the pH and the pressure did not influence the swelling process, and the first section of the swelling curve could be fitted by the Korsmeyer-Peppas equation. |
| Databáze: | OpenAIRE |
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