High-resolution MRI assessed carotid atherosclerotic plaque characteristics comparing men and women with elevated ApoB levels

Autor: Tianwen Han, Xue-Qiao Zhao, Hua Bai, Edward A. Gill, Jaekyoung Hong, Dongxiang Xu, Pathmaja Paramsothy, Daniel Isquith, Moni B. Neradilek
Rok vydání: 2019
Předmět:
Male
medicine.medical_specialty
Apolipoprotein B
030204 cardiovascular system & hematology
Risk Assessment
Neovascularization
03 medical and health sciences
Necrosis
0302 clinical medicine
Predictive Value of Tests
Risk Factors
Internal medicine
medicine
Humans
Radiology
Nuclear Medicine and imaging
Carotid Stenosis
Myocardial infarction
Prospective Studies
Vascular Calcification
Stroke
Aged
Randomized Controlled Trials as Topic
biology
Neovascularization
Pathologic
Rupture
Spontaneous
business.industry
Ultrasound
Middle Aged
medicine.disease
Prognosis
Fibrosis
Magnetic Resonance Imaging
Plaque
Atherosclerotic
Up-Regulation
Stenosis
Carotid Arteries
Apolipoprotein B-100
biology.protein
Cardiology
Female
medicine.symptom
Metabolic syndrome
Cardiology and Cardiovascular Medicine
business
030217 neurology & neurosurgery
Biomarkers
Calcification
Zdroj: The international journal of cardiovascular imaging. 36(3)
ISSN: 1875-8312
Popis: Previous studies demonstrated that men were more likely to have plaque rupture and are at greater risk for myocardial infarction and stroke than women. We evaluated differences in carotid plaque characteristics by MRI between men and women with mild-moderate atherosclerosis and elevated ApoB levels. One hundred eighty-two subjects (104 men and 78 women) with CAD or carotid stenosis (≥ 15% by ultrasound), ApoB ≥ 120 mg/dL and carotid MRI scan were included. Percent wall volume (%WV) was calculated as (wall volume/total vessel volume) × 100%. Three major plaque compositions, fibrous tissue (FT), calcification (CA) and lipid rich necrotic core (LRNC), were identified and quantified using published MRI criteria. Adventitial and plaque neovascularization as fractional plasma volume (Vp) and permeability as transfer constant (Ktrans) were analyzed using kinetic modeling. These characteristics were compared between men and women. Men, compared to women, were younger (54 ± 8 vs. 58 ± 8 years, p = 0.01), had higher rate of previous MI (46 vs. 26%, p = 0.005) but lower proportions of metabolic syndrome (37 vs. 59%, p = 0.003). After adjusting for between-gender differences, men were significantly more likely to have LRNC (OR 2.22, 95% CI 1.04–4.89, p = 0.04) and showed significantly larger %LRNC than women (diff = 4.3%, 95% CI 1.6–6.9%, p = 0.002), while %WV, FT, and CA were similar between men and women. There were no statistically significant differences in adventitial and plaque Vp or Ktrans. Men were significantly more likely to have LRNC and had larger LRNC than women. However, men and women showed relatively similar levels of adventitial and plaque neovascularization and permeability. Trial registration: NCT00715273 at ClinicalTrials.gov. Registered 15 July 2008, retrospectively registered.
Databáze: OpenAIRE
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