Diagnostic accuracy of a smartphone bedside test to assess the fixation suppression of the vestibulo-ocular reflex: when nothing else matters
Autor: | Florin Gandor, Georg Ebersbach, Doreen Gruber, Hannelore Neuhauser, Hans-Jochen Heinze, Manfred Tesch, Thomas Lempert |
---|---|
Rok vydání: | 2020 |
Předmět: |
Adult
Male genetic structures Video Recording Internet portal Diagnostic accuracy Nystagmus Pathologic Short Commentary Cerebellar Diseases Nothing Bedside test Humans Eye Movement Measurements Aged Aged 80 and over Cerebellar syndrome Vestibulo-ocular reflex Fixation suppression of the vestibulo-ocular reflex Correction Reflex Vestibulo-Ocular Middle Aged Neurology Point-of-Care Testing Fixation (visual) Reflex Optometry Female sense organs Smartphone Neurology (clinical) Vestibulo–ocular reflex Psychology |
Zdroj: | Journal of Neurology |
ISSN: | 1432-1459 0340-5354 |
Popis: | Objective Validation of a bedside test to objectify the fixation suppression of the vestibulo-ocular reflex (FS-VOR) in patients with a cerebellar syndrome and healthy controls. Methods The vestibulo-ocular reflex and its fixation suppression were assessed by video-nystagmography (VNG) in 20 healthy subjects (mean age 56 ± 15) and 19 patients with a cerebellar syndrome (mean age 70 ± 11). The statistical cutoff delineating normal from pathological FS-VOR was determined at the 2.5th percentile of the normal distribution of the healthy cohort. VNG was then compared to a bedside test, where eye movements were recorded with a smartphone while patients were rotated on a swivel chair at a defined speed and amplitude. These videos were rated as normal or pathological FS-VOR by six blinded raters, and results compared to VNG. Results VNG in healthy controls showed FS-VOR with a reduction of nystagmus beats by 95.0% ± 7.2 (mean ± SD). The statistical cutoff was set at 80.6%. Cerebellar patients reduced nystagmus beats by only 26.3% ± 25.1. Inter-rater agreement of the smartphone video ratings was 85%. The sensitivity of the video ratings to detect an impaired FS-VOR was 99%, its specificity 92%. Inter-test agreement was 91%. Conclusion The smartphone bedside test is an easily performed, reliable, sensitive, specific, and inexpensive alternative for assessing FS-VOR. |
Databáze: | OpenAIRE |
Externí odkaz: |