Additional file 1 of Dimethyl itaconate, an itaconate derivative, exhibits immunomodulatory effects on neuroinflammation in experimental autoimmune encephalomyelitis

Autor: Ping-Chang Kuo, Wen-Tsan Weng, Scofield, Barbara A., Hallel C. Paraiso, Brown, Dennis A., Wang, Pei-Yu, I-Chen Yu, Jui-Hung Yen
Rok vydání: 2020
ISSN: 3000-5000
DOI: 10.6084/m9.figshare.12218909
Popis: Additional file 1: Figure S1. C57BL/6 mice were immunized with MOG35-55 and administered i.p. with vehicle or DMI every day starting from day 3 post-immunization. The clinical score of EAE mice treated with (A) vehicle, DMI 300 mg/kg (n=5/group), (B) DMI 500 mg/kg (n=10/group) or DMI 600 mg/kg (n=10/group) was followed for a period of 30 days. The incidence and mortality rate of vehicle- and DMI-treated EAE mice were accessed, and the mean ± SEM of onset of disease, maximum score and cumulative score (day 1 to day 30 post-immunization) in vehicle- and DMI-treated EAE was also calculated. Statistical significance was determined as: *p
Databáze: OpenAIRE