Pharmacological correction of etoposide ovariotoxicity
| Autor: | E. A. Timina, Yu. A. Shchemerova, A. V. Pakhomova, T. G. Borovskaya, V. E. Gol’dberg, A. V. Perova |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
medicine.medical_specialty
Ovary Fertility Agents Female General Medicine Biology Pharmacology Antineoplastic Agents Phytogenic Buserelin General Biochemistry Genetics and Molecular Biology Rats Endocrinology Combined treatment medicine.anatomical_structure Internal medicine medicine Animals Combined therapy Female Rats Wistar Etoposide After treatment medicine.drug |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 143:614-616 |
| ISSN: | 1573-8221 0007-4888 |
| DOI: | 10.1007/s10517-007-0196-6 |
| Popis: | The possibility of reducing the ovariotoxicity of antitumor drug etoposide with buserelin, a hypothalamic regulator of pituitary function, was studied in female Wistar rats. Quantitative analysis of ovarian structural and functional elements on serial sections through the entire organ showed that 3 months after combined treatment with etoposide and buserelin, the morphological picture of the ovarian glands did not differ from that in intact animals of the same age, while etoposide monotherapy led to earlier development of atrophic processes. Six months after treatment, the number of bi- and multilayer follicles was significantly higher in rats receiving combined therapy compared to animals treated with etoposide alone. |
| Databáze: | OpenAIRE |
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