Age at menarche as a prognostic factor in human breast cancer
| Autor: | Vernhes Jc, A. Carré, A.M. Mandard, T. Delozier, D. Brune, Juret P, Couette Je |
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| Rok vydání: | 1976 |
| Předmět: |
medicine.medical_specialty
Prognostic factor Adolescent medicine.medical_treatment Breast Neoplasms Early menarche Female patient medicine Humans Child Nodal involvement Gynecology Menarche Obstetrics business.industry Age Factors Cancer General Medicine medicine.disease Prognosis Lymphatic Metastasis Female business Human breast Mastectomy |
| Zdroj: | European journal of cancer. 12(9) |
| ISSN: | 0014-2964 |
| Popis: | An analysis of a series of 926 female patients, of whom 755 were followed for 3 years and 647 for 5 years after mastectomy, revealed age at menarche to be a valuable prognosticator. Survival rates were the lowest for women who had very early menarche (≦ 11 years of age) but prognosis improved progressively with increase in menarchial age. Optimal menarchial age was found to be at age 15 ; onset of menses beyond this age was once again associated with an unfavorable outcome. The possible relationship between age at menarche and axillary node involvement was then examined from two points of view in an effort to establish whether early menarche would be associated with extensive nodal involvement, or whether it would retain its unfavorable prognostic significance independently of the extent of this involvement. Both of these hypotheses were found to be plausible in our series. It is stressed that further research on larger study populations is required before definitive conclusions can be drawn. |
| Databáze: | OpenAIRE |
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