Methotrexate loaded in alginate beads for controlled drug release against breast cancer

Autor:	Zahra Taran, Sepideh Yektaniroumand Digehsaraei, Mojtaba Salouti, Bahram Amini, Sanaz Mahmazi, Mohsen Kalantari
Rok vydání:	2022
Předmět:	Drug Liberation Methotrexate Alginates Tumor Necrosis Factor-alpha Genetics Humans Female Breast Neoplasms General Medicine bcl-2-Associated X Protein
Zdroj:	Gene. 851
ISSN:	1879-0038
Popis:	Methotrexate (MTX), as a folate antagonist is used for breast cancer chemotherapy, but its application due to the adverse side effects was limited. In this study, MTX were encapsulated in magnetic alginate beads coated with glutaraldehyde to control its release in order to reduce the side effects and improve its stability. The complex was characterized by physicochemical studies. The encapsulation efficiency was 75 % and the complex showed acceptable controlled release behavior. The cell cytotoxicity assessed using methylthiazol tetrazolium (MTT) method showed that magnetic alginate beads-MTX, in lower dosage has higher anticancer effect compared to the free MTX. The real-time polymerase chain reaction (PCR) was used to evaluate apoptotic factors Bcl
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42cad72e24b7f3e3c2ba0a517fbd9230 https://pubmed.ncbi.nlm.nih.gov/36257469 Zobrazit plný text záznamu Full Text from ScienceDirect