Interventional strategies in early atherosclerosis

Autor: Pantaleo Giannuzzi, Marinella Gattone
Rok vydání: 2006
Předmět:
Pulmonary and Respiratory Medicine
medicine.medical_specialty
medicine.medical_treatment
Adrenergic beta-Antagonists
Psychological intervention
early atherosclerosis
lcsh:Medicine
Disease
non-invasive imaging
Coronary Angiography
Asymptomatic
Magnetic resonance angiography
Antioxidants
Pharmacotherapy
Internal medicine
Medicine
Humans
Life Style
Subclinical infection
Ultrasonography
Clinical Trials as Topic
medicine.diagnostic_test
business.industry
lcsh:R
cardiovascular prevention
Atherosclerosis
Calcium Channel Blockers
Surgery
Exercise Therapy
Blood pressure
Carotid Arteries
Cardiovascular Diseases
Cardiology
Smoking cessation
Drug Therapy
Combination
Smoking Cessation
medicine.symptom
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Cardiology and Cardiovascular Medicine
business
Tomography
X-Ray Computed
Magnetic Resonance Angiography
Platelet Aggregation Inhibitors
Zdroj: Scopus-Elsevier
Monaldi Archives for Chest Disease, Vol 66, Iss 1 (2016)
ISSN: 1122-0643
Popis: Atherosclerosis remains clinically mute for a long time and frequently manifests itself with an acute cardiovascular event; therefore, the possibility to detect the disease in a subclinical phase and to reduce or reverse its progression is an issue of relevance. Non-invasive diagnostic procedures such as B-mode ultrasonography of carotid intima-media thickness (CIMT), electron beam computed tomography (EBCT) and magnetic resonance angiography (MRA) allow to identify atherosclerotic disease in its early phases, to evaluate the disease progression and monitor the effects of interventions. In recent years, several therapeutic strategies have been adopted over time to slow early atherosclerosis in asymptomatic individuals at intermediate/high cardiovascular risk. Prospective trials employing multifactorial non-pharmacological interventions (diet, exercise, smoking cessation) have demonstrated a favorable effect on progression of atherosclerosis. Hence lifestyle modification may be an effective therapeutic strategy to be adopted as a first step and a highly cost-effective intervention in a preclinical setting involving a large number of individuals. Drugs should be considered as a second step or should be associated to further reduce the risk in individuals at high probability of future events, who require more intensive interventions. Reducing low-density lipoprotein levels, blood pressure and platelet aggregation seems to be the most effective intervention in these subjects, whereas the treatment of emerging coronary risk factors, e.g. oxidative stress, inflammatory activation and infections has not produced the expected protective effect.
Databáze: OpenAIRE
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