Correction: Neuroendocrine modulation sustains the
| Autor: | Ben Mulcahy, Ralf Schnabel, Wesley Hung, Linjiao Luo, Valeriya Laskova, Anne Wiekenberg, Yangning Lu, Aravinthan D. T. Samuel, David M. Miller, Douglas Holmyard, Daniel Findeis, Yixin Qu, Mei Zhen, Jun Meng, Yan Li, Rebecca McWhirter, Maria Lim, Chi-Yip Ho, John A. Calarco, Jyothsna Chitturi, Ni Ji |
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| Rok vydání: | 2017 |
| Předmět: |
motor state
QH301-705.5 Science peptidergic neurons RNA profiling General Biochemistry Genetics and Molecular Biology Neural Pathways Animals neuroendocrine Biology (General) Caenorhabditis elegans Physics Neurons Neurotransmitter Agents General Immunology and Microbiology Behavior Animal General Neuroscience Neuropeptides Correction General Medicine Neurosecretory Systems Developmental Biology and Stem Cells Modulation C. elegans Medicine State (computer science) Stem cell Developmental biology Neuroscience human activities Locomotion Research Article |
| Zdroj: | eLife eLife, Vol 6 (2017) |
| ISSN: | 2050-084X |
| Popis: | Neuromodulators shape neural circuit dynamics. Combining electron microscopy, genetics, transcriptome profiling, calcium imaging, and optogenetics, we discovered a peptidergic neuron that modulates C. elegans motor circuit dynamics. The Six/SO-family homeobox transcription factor UNC-39 governs lineage-specific neurogenesis to give rise to a neuron RID. RID bears the anatomic hallmarks of a specialized endocrine neuron: it harbors near-exclusive dense core vesicles that cluster periodically along the axon, and expresses multiple neuropeptides, including the FMRF-amide-related FLP-14. RID activity increases during forward movement. Ablating RID reduces the sustainability of forward movement, a phenotype partially recapitulated by removing FLP-14. Optogenetic depolarization of RID prolongs forward movement, an effect reduced in the absence of FLP-14. Together, these results establish the role of a neuroendocrine cell RID in sustaining a specific behavioral state in C. elegans. DOI: http://dx.doi.org/10.7554/eLife.19887.001 |
| Databáze: | OpenAIRE |
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