A study on the geophylogeny of clinical and environmental Vibrio cholerae in Kenya
| Autor: | Samuel Kariuki, Robert Onsare Sanaya, Gunturu Revathi, Jane Muyodi, Julian Parkhill, Ankur Mutreja, Racheal W. Kimani, Ahmed Abade Mohamed, Nicholas R. Thomson, Joyce Mwituria, Gordon Dougan, John Kiiru |
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| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Kenya
Molecular Sequence Data lcsh:Medicine Biology medicine.disease_cause Genome El Tor Microbiology 03 medical and health sciences Phylogenetics parasitic diseases medicine Humans Clade lcsh:Science Vibrio cholerae Phylogeny 030304 developmental biology Genetics 0303 health sciences Multidisciplinary Phylogenetic tree 030306 microbiology lcsh:R biology.organism_classification medicine.disease Cholera 3. Good health lcsh:Q Research Article |
| Zdroj: | PLoS ONE, Vol 8, Iss 9, p e74829 (2013) PLoS ONE |
| ISSN: | 1932-6203 |
| Popis: | Cholera remains a significant public health challenge in many sub-Saharan countries including Kenya. We have performed a combination of phylogenetic and phenotypic analysis based on whole genome DNA sequences derived from 40 environmental and 57 clinical V. cholerae from different regions of Kenya isolated between 2005 and 2010. Some environmental and all clinical isolates mapped back onto wave three of the monophyletic seventh pandemic V. cholerae El Tor phylogeny but other environmental isolates were phylogenetically very distinct. Thus, the genomes of the Kenyan V. cholerae O1 El Tor isolates are clonally related to other El Tor V. cholerae isolated elsewhere in the world and similarly harbour antibiotic resistance-associated STX elements. Further, the Kenyan O1 El Tor isolates fall into two distinct clades that may have entered Kenya independently. |
| Databáze: | OpenAIRE |
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