Telomere length in peripheral blood leukocytes and risk of renal cell carcinoma
| Autor: | Nahyeon Kang, Chang Dong Yeo, Philippe E. Spiess, Hui Yi Lin, Alex M. Parker, Jong Y. Park, Seung Joon Kim, Wade J. Sexton, Hyun Y. Park, Samuel O. Antwi, Giuliano Di Pietro, Shohreh I. Dickinson, Hung N. Luu, Selina Radlein |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Oncology
Cancer Research medicine.medical_specialty renal cancer medicine.disease_cause urologic and male genital diseases law.invention Renal cell carcinoma law Internal medicine Cancer screening medicine Radiology Nuclear Medicine and imaging Polymerase chain reaction Genetic association risk Telomere length business.industry Cancer medicine.disease female genital diseases and pregnancy complications Telomere Biomarker (medicine) Original Article Carcinogenesis business |
| Zdroj: | Translational Cancer Research |
| ISSN: | 2219-6803 2218-676X |
| Popis: | Background Telomeres are essential for chromosomal stability and may play a key role in carcinogenesis. Telomere length is suggested as a tentative biomarker of risk for renal cell carcinoma (RCC). However, results of previous association studies between telomere length and risk for RCC are inconsistent. Methods We evaluated RCC risk in relation to peripheral blood leukocyte telomere length using a hospital-based case–control study of 169 RCC cases and 189 controls. Cases were histologically-confirmed RCC patients who were treated at the Moffitt Cancer Center (Tampa, FL). Controls with no history of cancer underwent a screening exam at the Lifetime Cancer Screening Center at Moffitt Cancer Center to rule out the presence of cancer. Relative telomere length (RTL) was measured by quantitative real-time polymerase chain reaction (PCR) using peripheral blood leukocyte DNA. Logistic regression was used to determine the association between RTL and RCC risk. Results As expected, increasing age was inversely correlated with RTL (Pearson r=−0.213, P=0.003) among controls but not cases. Average RTL was significantly shorter in cases as compared with controls [mean ± standard deviation (SD): 3.18±1.50 and 4.39±1.99, respectively, P |
| Databáze: | OpenAIRE |
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