Interference of O.C.T. embedding compound with hormone receptor assays
| Autor: | William C. Maslow, Helmut Muensch |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
medicine.medical_specialty
medicine.drug_class Progesterone receptor binding Estrogen receptor Breast Neoplasms Biology Fixatives Pregnancy Internal medicine Progesterone receptor medicine Animals Frozen Sections Humans Estrogen binding Estrogen receptor beta Uterus General Medicine Hormone receptor binding Microtomy Endocrinology Receptors Estrogen Estrogen Female Rabbits Receptors Progesterone Estrogen receptor alpha |
| Zdroj: | American journal of clinical pathology. 82(1) |
| ISSN: | 0002-9173 |
| Popis: | The interference of O.C.T.® (Optimum Cutting Temperature) embedding compound with the determination of estrogen and progesterone receptor analysis in rabbit uterus cytosol and human breast cancer tissue was investigated. It was determined that O.C.T. Compound reduces binding in rabbit uterus cytosol at concentrations greater than 1%. Hormone receptor binding greatly was reduced in human breast cancer tissues from O.C.T. embedded tissues when compared with the untreated tissue of the same patients. Progesterone receptor binding was affected more strongly than estrogen binding. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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