Small-Cell Carcinoma With an Epidermal Growth Factor Receptor Mutation in a Never-Smoker With Gefitinib-Responsive Adenocarcinoma of the Lung
| Autor: | Arkadiusz Z. Dudek, Alexander M. Truskinovsky, Maureen F. Zakowski, Atul Kapoor, Naheed Alam, Marc Ladanyi, Karen S. Gustafson |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Pulmonary and Respiratory Medicine
Oncology Cancer Research medicine.medical_specialty Lung Neoplasms Antineoplastic Agents Adenocarcinoma Small-cell carcinoma Gefitinib Carcinoma Non-Small-Cell Lung Internal medicine medicine Adenocarcinoma of the lung Humans Epidermal growth factor receptor Carcinoma Small Cell Lung cancer neoplasms Aged EGFR inhibitors biology business.industry Liver Neoplasms medicine.disease respiratory tract diseases ErbB Receptors Mutation Quinazolines Mutation testing biology.protein Female business medicine.drug |
| Zdroj: | Clinical Lung Cancer. 11:E1-E4 |
| ISSN: | 1525-7304 |
| Popis: | Activating mutations in the epidermal growth factor receptor (EGFR) gene are extremely rare in small-cell lung cancer (SCLC). Here, we present a case of an EGFR-mutant gefitinib-responsive non-small-cell lung cancer (NSCLC) of adenocarcinoma histology occurring in a never-smoker followed by subsequent diagnosis of metastatic SCLC carrying an EGFR mutation. Although gefitinib therapy of the primary NSCLC resulted in disease control for over 3 years, the patient subsequently developed metastatic SCLC to the liver. Epidermal growth factor receptor mutation analysis revealed that the exon 21 L858R activating mutation was present in both the original lung adenocarcinoma and the metastatic SCLC. We hypothesize that SCLC either evolved from the previously diagnosed NSCLC or that both arose from a common precursor. Further comparative molecular analysis of these histologically distinct tumors would be of value to better understand the potential role of EGFR in the pathogenesis of SCLC in never-smokers, and the role of selection for an EGFR-mutant SCLC subclone as an unusual mechanism of acquired resistance to EGFR inhibitors in NSCLC. |
| Databáze: | OpenAIRE |
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