Newborn micronutrient status biomarkers in a cluster-randomized trial of antenatal multiple micronutrient compared with iron folic acid supplementation in rural Bangladesh
| Autor: | Hasmot Ali, Kerry Schulze, Afreen Zaman Khan, Lee S.F. Wu, Emorn Udomkesmalee, Saijuddin Shaikh, Keith P. West, Alison D. Gernand, Sucheta Mehra, Parul Christian, Abu Ahmed Shamim, Alain B. Labrique, Pongtorn Sungpuag |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Vitamin
Adult Rural Population medicine.medical_specialty medicine.medical_treatment Iron Medicine (miscellaneous) Gastroenterology Cobalamin AcademicSubjects/MED00160 chemistry.chemical_compound Young Adult AcademicSubjects/MED00060 Folic Acid Double-Blind Method Pregnancy newborn Internal medicine medicine Vitamin D and neurology Cluster Analysis Humans Bangladesh Nutrition and Dietetics biology business.industry Vitamin E International Nutrition Retinol Infant Newborn Maternal Nutritional Physiological Phenomena Micronutrient medicine.disease Fetal Blood Ferritin Original Research Communications chemistry micronutrients Dietary Supplements biology.protein cord blood Female business Biomarkers |
| Zdroj: | The American Journal of Clinical Nutrition |
| ISSN: | 1938-3207 |
| Popis: | Background Daily antenatal multiple micronutrient (MM) compared with iron folic acid (IFA) supplementation from early pregnancy improved birth outcomes and maternal micronutrient status in rural Bangladesh, but effects on newborn status are unknown. Objective We examined cord blood micronutrient biomarkers in relation to antenatal MM and IFA supplementation and maternal gestational micronutrient status in rural Bangladeshi newborns. Design In a double-blinded, cluster-randomized trial of antenatal IFA or MM (with the same IFA content), we analyzed cord blood plasma from 333 singleton births, and corresponding maternal plasma at 32.5 ± 2.6 wk of gestation, for ferritin (iron stores), folate, cobalamin (vitamin B-12), retinol (vitamin A), 25-hydroxyvitamin D [25(OH)D, vitamin D status], α-tocopherol (vitamin E), zinc, thyroglobulin, and free thyroxine (iodine status). Intervention effects and associations were determined using linear regression, exploring maternal status as a mediator of intervention effects on cord biomarkers. Results The MM intervention increased cord ferritin (mean: +12.4%; 95% CI: 1.3, 24.6%), 25(OH)D (mean: +14.7%; 95% CI: 4.8, 25.6%), and zinc (mean: +5.8%; 95% CI: 1.0, 10.8%). Cord folate (mean: +26.8%; 95% CI: 19.6, 34.5%), cobalamin (mean: +31.3%; 95% CI: 24.6, 38.3%), 25(OH)D (mean: +26.7%; 95% CI: 23.2, 30.3%), α-tocopherol (mean: +8.7%; 95% CI: 3.6, 13.7%), zinc (mean: +2.3%; 95% CI: 0.5, 4.2%), thyroglobulin (mean: +20.1%; 95% CI: 9.0, 32.2%) and thyroxine (mean: +1.5%; 95% CI: 0.0, 3.0%) increased per 1-SD increment in maternal status (all P |
| Databáze: | OpenAIRE |
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