Adjusted calcium concentration as a predictor of ionized hypocalcemia in hypoalbuminemic dogs
| Autor: | Peter S Chapman, Fiamma De Witte, Alan Klag |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Veterinary medicine Serum protein Serum albumin canine Standard Article total calcium Gastroenterology Hyperphosphatemia ionized calcium Dogs Internal medicine SF600-1100 medicine Animals Nephrology/Urology Hypoalbuminemia Dog Diseases Serum Albumin Retrospective Studies Calcium metabolism General Veterinary biology Hypocalcemia business.industry protein‐losing enteropathy Albumin medicine.disease Standard Articles biology.protein Hypercalcemia Adjusted calcium Calcium SMALL ANIMAL Total calcium business |
| Zdroj: | Journal of Veterinary Internal Medicine Journal of Veterinary Internal Medicine, Vol 35, Iss 5, Pp 2249-2255 (2021) |
| ISSN: | 1939-1676 |
| Popis: | Background Ionized calcium (iCa) is the biologically active fraction of total calcium (tCa) with clinical relevance to evaluate calcium homeostasis, but not all primary veterinarians have access to serum iCa. Formulas that adjust tCa to correct for variability in serum protein concentrations were not designed to predict iCa and are considered unreliable surrogates for iCa. Objectives To determine whether adjusted calcium concentration (aCa) can predict ionized hypocalcemia in hypoalbuminemic dogs without hyperphosphatemia. Animals A total of 262 hypoalbuminemic dogs without hyperphosphatemia. Methods Retrospective review of paired tCa and iCa. Patients were included if serum albumin concentration was ≤2.5 g/L and serum phosphorus concentration was ≤5 mg/dL. The aCa was calculated using tCa (mg/dL) − serum albumin concentration (g/dL) + 3.5 (g/dL). Sensitivity, specificity, positive (PPVs) and negative (NPVs) predictive values, and accuracy were determined for tCa and aCa at predicting any ( |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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