On-chip transporting arresting and characterizing individual nano-objects in biological ionic liquids
| Autor: | Maarit Suomalainen, Dimos Poulikakos, Christian Höller, Hadi Eghlidi, Gabriel Schnoering, Urs F. Greber |
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| Přispěvatelé: | University of Zurich, Poulikakos, Dimos |
| Rok vydání: | 2020 |
| Předmět: |
chemistry.chemical_classification
0303 health sciences 1000 Multidisciplinary Multidisciplinary Chemistry Nanoparticle Nanotechnology 02 engineering and technology Polymer 021001 nanoscience & nanotechnology 10124 Institute of Molecular Life Sciences 3. Good health 03 medical and health sciences chemistry.chemical_compound Electrokinetic phenomena Nano Ionic liquid Particle 570 Life sciences biology Nanotopography 0210 nano-technology Nanoscopic scale 030304 developmental biology |
| Zdroj: | Science Advances, 7 (27) |
| ISSN: | 2375-2548 |
| Popis: | Understanding and controlling the individual behavior of nanoscopic matter in liquids, the environment in which many such entities are functioning, is both inherently challenging and important to many natural and man-made applications. Here, we transport individual nano-objects, from an assembly in a biological ionic solution, through a nanochannel network and confine them in electrokinetic nanovalves, created by the collaborative effect of an applied ac electric field and a rationally engineered nanotopography, locally amplifying this field. The motion of so-confined fluorescent nano-objects is tracked, and its kinetics provides important information, enabling the determination of their particle diffusion coefficient, hydrodynamic radius, and electrical conductivity, which are elucidated for artificial polystyrene nanospheres and subsequently for sub–100-nm conjugated polymer nanoparticles and adenoviruses. The on-chip, individual nano-object resolution method presented here is a powerful approach to aid research and development in broad application areas such as medicine, chemistry, and biology. ISSN:2375-2548 |
| Databáze: | OpenAIRE |
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