Theoretical and Experimental Tests of a Chromosomal Fingerprint for Densely Ionizing Radiation Based on F Ratios Calculated from Stable and Unstable Chromosome Aberrations

Autor: F. S. Hill, Tracy Chui-hsu Yang, K. George, Marco Durante, S. W. Oram, Wen Deng, J. N. Lucas, C. L. Owens, Honglu Wu
Přispěvatelé: J. N., Luca, W., Deng, S. W., Oram, F. S., Hill, Durante, Marco, K., George, H., Wu, C. L., Owen, T., Yang
Rok vydání: 1999
Předmět:
Zdroj: Radiation Research. 151:85
ISSN: 0033-7587
DOI: 10.2307/3579752
Popis: In the present study, F ratios for both stable chromosome aberrations, i.e. ratios of translocations to pericentric inversions, and unstable aberrations, i.e. dicentrics and centric rings, were measured using fluorescence in situ hybridization. F ratios for stable aberrations measured after exposure to low (2.89 Gy 60Co gamma rays) and high-LET (0.25 Gy 56Fe ions; 1.25 Gy 56Fe ions; 3.0 Gy 12C ions) radiation were 6.5 +/- 1.5, 4.7 +/- 1.6, 9.3 +/- 2.5 and 10.4 +/- 3.0, respectively. F ratios for unstable aberrations measured after low (2.89 Gy 60Co gamma rays) and high-LET (0.25 Gy 56Fe ions; 3.0 Gy 12C ions) radiations were 6.5 +/- 1.6, 6.3 +/- 2.3 and 11.1 +/- 3.7, respectively. No significant difference between the F ratios for low- and high-LET radiation was found. Further tests on the models for calculation of the F ratio proposed by Brenner and Sachs (Radiat. Res. 140, 134-142, 1994) showed that the F ratio may not be straightforward as a practical fingerprint for densely ionizing radiation.
Databáze: OpenAIRE