Effects of a lifestyle intervention on endothelial function in men on long-term androgen deprivation therapy for prostate cancer
| Autor: | Stephen E Gilbert, John M. Saxton, Liam Bourke, Derek J. Rosario, Edward M. Winter, Garry A. Tew, Caroline Fairhurst |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Male
Cancer Research medicine.medical_specialty Antineoplastic Agents Hormonal Health Behavior Blood lipids androgen deprivation therapy 030204 cardiovascular system & hematology law.invention prostatic neoplasm RC0254 Androgen deprivation therapy 03 medical and health sciences Prostate cancer 0302 clinical medicine endothelial function Randomized controlled trial Quality of life cardiovascular disease Risk Factors law medicine Humans Treadmill Life Style Aged Aged 80 and over exercise business.industry Prostatic Neoplasms Androgen Antagonists Middle Aged medicine.disease C600 Confidence interval Diet B900 Blood pressure Oncology Cardiovascular Diseases 030220 oncology & carcinogenesis Clinical Study Quality of Life Physical therapy business |
| Zdroj: | British Journal of Cancer |
| ISSN: | 0007-0920 |
| Popis: | Background: Treatment of prostate cancer with androgen deprivation therapy (ADT) is associated with metabolic changes that have been linked to an increase in cardiovascular risk.\ud \ud Methods: This randomised controlled trial investigated the effects of a 12-week lifestyle intervention that included supervised exercise training and dietary advice on markers of cardiovascular risk in 50 men on long-term ADT recruited to an on-going study investigating the effects of such a lifestyle intervention on quality of life. Participants were randomly allocated to receive the intervention or usual care. Cardiovascular outcomes included endothelial function (flow-mediated dilatation (FMD) of the brachial artery), blood pressure, body composition and serum lipids. Additional outcomes included treadmill walk time and exercise and dietary behaviours. Outcomes were assessed before randomisation (baseline), and 6, 12 and 24 weeks after randomisation.\ud \ud Results: At 12 weeks, the difference in mean relative FMD was 2.2% (95% confidence interval (CI) 0.1–4.3, P=0.04) with an effect size of 0.60 (95% CI |
| Databáze: | OpenAIRE |
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