Homeostatic regulation of lipid droplet content in mammalian oocytes and embryos
| Autor: | Megumi Ibayashi, Junichiro Mitsui, Ryutaro Aizawa, Satoshi Tsukamoto |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Embryology
Swine Phospholipid Embryonic Development Preimplantation Embryos Mice chemistry.chemical_compound Oogenesis Endocrinology Pregnancy Lipid droplet medicine Animals Chemistry Embryogenesis Obstetrics and Gynecology Embryo Lipid Droplets Cell Biology Lipid Metabolism Oocyte Cell biology Blastocyst medicine.anatomical_structure Reproductive Medicine Cytoplasm Oocytes Cattle Female Homeostasis |
| Zdroj: | Reproduction. 162:R99-R109 |
| ISSN: | 1741-7899 1470-1626 |
| Popis: | Lipid droplets (LDs) consist of a core of neutral lipids such as triacylglycerols and cholesteryl esters covered by a phospholipid monolayer. Recent studies have shown that LDs not only store neutral lipids but are also associated with various physiological functions. LDs are found in most eukaryotic cells and vary in size and quantity. It has long been known that mammalian oocytes contain LDs. Porcine and bovine oocytes contain substantial amounts of LDs, which cause their cytoplasm to darken, whereas mouse and human oocytes are translucent due to their low LD content. A sufficient amount of LDs in mammalian oocytes has been thought to be associated with oocyte maturation and early embryonic development, but the necessity of LDs has been questioned because embryonic development proceeds normally even when LDs are removed. However, recent studies have revealed that LDs play a crucial role during implantation and that maintaining an appropriate amount of LDs is important for early embryonic development, even in mammalian species with low amounts of LDs in their oocytes. This suggests that a fine-tuned balance of LD content is essential for successful mammalian embryonic development. In this review, we discuss the physiological importance of LDs in mammalian oocytes and preimplantation embryos based on recent findings on LD biology. |
| Databáze: | OpenAIRE |
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