Effect of pyridoxal 5′-phosphate on human neutrophil aggregationin vitro
| Autor: | Salvatore Chirumbolo, M Nicoli, M Schinella, Giuseppe Lippi |
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| Rok vydání: | 1995 |
| Předmět: |
Adult
Male Vitamin medicine.medical_specialty Pyridoxal 5-Phosphate Human neutrophil Neutrophils Clinical Biochemistry In Vitro Techniques Aggregation chemistry.chemical_compound Internal medicine Mole medicine Humans Pyridoxal 5′-phosphate Pyridoxal Cell Aggregation Polymorphonuclear leukocyte Dose-Response Relationship Drug Neutrophil In vitro Endocrinology chemistry Biochemistry Pyridoxal Phosphate Phorbol Tetradecanoylphorbol Acetate |
| Zdroj: | International Journal of Clinical & Laboratory Research. 25:99-103 |
| ISSN: | 1434-4467 0940-5437 |
| Popis: | Pyridoxal 5'-phosphate inhibited polymorphonuclear leukocyte aggregation in vitro in a dose-dependent fashion at concentrations ranging from 0.5 to 0.001 mmol/l. At pyridoxal 5'-phosphate concentrations between 0.4 and 0.5 mmol/l mean inhibition of aggregation was about 50%-60%. In this range, and at lower pyridoxal 5'-phosphate concentrations, phorbol myristate acetate-activated polymorphonuclear leukocytes showed a normal increase in volume, whereas swelling was inhibited at higher concentrations of pyridoxal 5'-phosphate. Since pyridoxal 5'-phosphate can be administered as a vitamin to man without any relevant side-effects its role as a physiological anti-aggregant of polymorphonuclear leukocytes warrants further investigation. |
| Databáze: | OpenAIRE |
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