Histamine Sensitization of Mice by Trichinella spiralis Infection
| Autor: | John J. Munoz, R. K. Bergman, F. Sogandares-Bernal |
|---|---|
| Rok vydání: | 1974 |
| Předmět: |
Male
Long lasting Adult female Oral infection Trichinella fungi Trichinella spiralis infection Histamine-Sensitizing Factor Biology General Biochemistry Genetics and Molecular Biology Drug Hypersensitivity Lethal Dose 50 Mice chemistry.chemical_compound medicine.anatomical_structure chemistry Larva Immunology medicine Animals Sensitization Histamine |
| Zdroj: | Experimental Biology and Medicine. 147:524-526 |
| ISSN: | 1535-3699 1535-3702 |
| DOI: | 10.3181/00379727-147-38379 |
| Popis: | SummaryInfection of mice with T. spiralis larvae collected from infected muscle induce a state of histamine hypersensitivity in CFW mice. This hypersensitivity can be detected 14 days after oral infection with larvae, and coincides with the time when larvae from the adult female penetrate the intestinal wall and first appear in striated muscle. The LD50 of histamine for infected mice was 0.1785 mg, which is of the same order of magnitude as the LD50 in mice treated with histamine sensitizing factor of B. pertussis. The hypersensitivity induced by T. spiralis seems to be long lasting. |
| Databáze: | OpenAIRE |
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