Risky Sex and HIV Acquisition Among HIV Serodiscordant Couples in Zambia, 2002-2012: What Does Alcohol Have To Do With It?
| Autor: | Bellington Vwalika, Pamina M. Gorbach, Susan Allen, W. Scott Comulada, Naw Htee Khu, Marjan Javanbakht, Elwyn Chomba, Ilene Brill, Kristin M. Wall, Dvora Joseph Davey, William Kilembe, Amanda Tichacek, Joseph Mulenga |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Male Sexual behavior HIV Infections Cohort Studies Alcohol Use and Health Substance Misuse Unsafe Sex Risk Factors Prevalence Odds Ratio HIV serodiscordant couples Young adult Hazard ratio Age Factors Middle Aged 3. Good health HIV transmission Alcoholism Infectious Diseases Sexual Partners Serodiscordant Cohort Public Health and Health Services HIV/AIDS Female Public Health Infection Psychology Alcohol use Social psychology Cohort study Adult Social Work Social Psychology Alcohol Drinking Zambia 03 medical and health sciences Young Adult Clinical Research Behavioral and Social Science Humans Proportional Hazards Models Original Paper Proportional hazards model Public Health Environmental and Occupational Health Odds ratio 030112 virology Good Health and Well Being Logistic Models Alcoholic Intoxication Demography |
| Zdroj: | AIDS and behavior, vol 21, iss 7 AIDS and Behavior |
| Popis: | In this paper we evaluate the effects of heavy alcohol consumption on sexual behavior, HIV acquisition, and antiretroviral treatment (ART) initiation in a longitudinal open cohort of 1929 serodiscordant couples in Lusaka, Zambia from2002 to2012. We evaluated factors associated with baseline heavy alcohol consumption and its association with condomless sex with the study partner, sex outside of the partnership, and ART initiation using multivariable logistic regression. We estimated the effect of alcohol consumption on HIV acquisition using multivariable Cox models. Baseline factors significantly associated with women's heavy drinking (drunk weekly or more in 12-months before enrollment) included woman's older age (adjusted prevalence odds ratio [aPOR]=1.04), partner heavy drinking (aPOR=3.93), and being HIV-infected (aPOR=2.03). Heavy drinking among men was associated with less age disparity with partner (aPORper year disparity=0.97) and partner heavy drinking (aPOR=1.63). Men's being drunk daily (aOR=1.18), women's being drunk less than monthly (aOR=1.39) vs. never drunk and being in a male HIV-negative and female HIV-positive union (aOR=1.45) were associated with condomless sex. Heavy alcohol use was associated with having 1 or more outside sex partners among men (aOR drunk daily=1.91, drunk weekly=1.32, drunk monthly =2.03 vs. never), and women (aOR drunk monthly=2.75 vs. never). Being drunk weekly or more increased men's risk of HIV acquisition (adjusted hazard ratio [aHR]=1.72). Men and women being drunk weekly or more was associated (p |
| Databáze: | OpenAIRE |
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