Evaluation of primary hemostasis in neonates with a new in vitro platelet function analyzer
| Autor: | Eileen M. McMillan-Ward, Sara J. Israels, Mary Cheang, Timothy Cheang |
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| Rok vydání: | 2001 |
| Předmět: |
Adult
Male medicine.medical_specialty Pathology Platelet Function Tests Hematocrit Sensitivity and Specificity Von Willebrand factor Bleeding time Internal medicine von Willebrand Factor medicine Humans Platelet Whole blood Hemostasis Hematology medicine.diagnostic_test biology business.industry Age Factors Infant Newborn Fetal Blood Platelet Activation Cord blood Pediatrics Perinatology and Child Health Multivariate Analysis biology.protein Cardiology Regression Analysis Female business |
| Zdroj: | The Journal of pediatrics. 138(1) |
| ISSN: | 0022-3476 |
| Popis: | With the use of the PFA-100 platelet function analyzer to evaluate primary hemostasis in whole blood, measured as closure time (CT), neonates had shorter CTs than members of an adult control group. Multivariate analysis of measures that contribute to primary hemostasis showed that higher hematocrits and increased ristocetin cofactor activity were the best correlates for CTs of cord blood. These 2 factors may also enhance primary hemostasis in vivo and compensate for the impaired platelet function of the newborn. |
| Databáze: | OpenAIRE |
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