EGFR signaling in renal fibrosis
| Autor: | Shougang Zhuang, Na Liu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
kidney
Mini Review EGFR Disease Bioinformatics 03 medical and health sciences 0302 clinical medicine Fibrosis Renal fibrosis medicine Epidermal growth factor receptor transforming growth factor-β1 030304 developmental biology 0303 health sciences Kidney biology business.industry Mechanism (biology) fibrosis medicine.disease renal epithelial cells 3. Good health medicine.anatomical_structure Nephrology 030220 oncology & carcinogenesis Cancer research biology.protein Cyclin-dependent kinase 8 Animal studies business |
| Zdroj: | Kidney International Supplements |
| ISSN: | 2157-1716 2157-1724 |
| Popis: | Signaling through the epidermal growth factor receptor (EGFR) is involved in regulation of multiple biological processes, including proliferation, metabolism, differentiation, and survival. Owing to its aberrant expression in a variety of malignant tumors, EGFR has been recognized as a target in anticancer therapy. Increasingly, evidence from animal studies indicates that EGFR signaling is also implicated in the development and progression of renal fibrosis. The therapeutic value of EGFR inhibition has not yet been evaluated in human kidney disease. In this article, we summarize recent research into the role of EGFR signaling in renal fibrogenesis, discuss the mechanism by which EGFR regulates this process, and consider the potential of EGFR as an antifibrotic target. |
| Databáze: | OpenAIRE |
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