No differences in benzo(a)pyrene hydroxylase activity in the human immature placenta and in the human fetal liver from cigarette smoking and nonsmoking women
| Autor: | Eva Schlede, Horst Scholz |
|---|---|
| Rok vydání: | 1974 |
| Předmět: |
medicine.medical_specialty
Benzo(a)pyrene Hydroxylase Placenta education Gestational Age Mixed Function Oxygenases Hydroxylation chemistry.chemical_compound Cigarette smoking Pregnancy Internal medicine Humans Medicine Benzopyrenes Benzopyrene Hydroxylase reproductive and urinary physiology Carcinogen Morphine Derivatives Morphine biology business.industry Incidence (epidemiology) Smoking Obstetrics and Gynecology medicine.disease Enzyme assay medicine.anatomical_structure Endocrinology Liver chemistry embryonic structures Pediatrics Perinatology and Child Health biology.protein Female business |
| Zdroj: | Journal of Perinatal Medicine. 2:189-195 |
| ISSN: | 1619-3997 0300-5577 |
| DOI: | 10.1515/jpme.1974.2.3.189 |
| Popis: | Cigarette smoking during pregnancy has been shown to increase the incidence of abortions, premature deliveries and lighter weight of the newborns. However, an explicit explanation for these findings is still lacking and until now it cannot be excluded that the constitution of the pregnant woman who smokes might be related to these observations and not to the smoking habit per se [2, 5, 11, 24, 32, 33]. Besides these clinical findings it was demonstrated that in the term placenta the enzymatic hydroxylation of benzo(a)pyrene (BP), one of several carcinogens present in cigarette smoke, was found in almost all placentas from women with smoking habits during pregnancy but no or only little BP hydroxylase could be detected in the placentas from nonsmokers [13, 29, 30]. The relationship of the clinical findings and the ability of components of cigarette smoke to stimulate BP hydroxylation by enzymes in the placenta still remains to be clarified. The results of these studies have prompted our laboratory in late 1970 to evaluate whether in the immature placenta BP hydroxylase activity could be detected and whether there exists a correlation between the activity of this enzyme and the habit of cigarette smoking during the early phase of pregnancy. Since then, data were published showing that in the immature placenta the capacity to metabolize BP was not found in the placentas from nonsmokers, but the placentas from smokers metabolized BP, though being lower in the immature than in the term tissue. However, no enzyme activity was detectable in the placenta from smokers before the eleventh Curriculum vitae |
| Databáze: | OpenAIRE |
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