The efficacy comparison of classic ketogenic diet and modified Atkins diet in children with refractory epilepsy: a clinical trial
| Autor: | Zakiyeh Ebadi, Sina Raeisi, Sanaz Tahmasebi, Bita Poorshiri, Mohammad Barzegar, Shadi Shiva |
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| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty Drug Resistant Epilepsy animal structures Neurology Adolescent medicine.medical_treatment food.diet 03 medical and health sciences Epilepsy 0302 clinical medicine food Internal medicine Medicine Humans 030212 general & internal medicine Child Seizure frequency Atkins diet business.industry General Medicine medicine.disease Clinical trial Treatment Outcome Tolerability Child Preschool Refractory epilepsy Female Neurology (clinical) business Diet Ketogenic 030217 neurology & neurosurgery Diet High-Protein Low-Carbohydrate Ketogenic diet Follow-Up Studies |
| Zdroj: | Acta neurologica Belgica. 121(2) |
| ISSN: | 2240-2993 |
| Popis: | Dietary therapy has an important role in the therapeutic process in children suffering refractory epilepsy. There are two kinds of dietary therapy which are the most common in children with refractory epilepsy: The classic ketogenic diet (KD) and the modified Atkins diet (MAD). The purpose of the present study was to compare the efficacy, tolerability, and compliance of these two dietary therapies in the children who have refractory epilepsy during 6 months of treatment. From March 2017 to November 2018, 45 children aged 2–15 years who had refractory epilepsy were randomly allocated in KD or MAD group. The intervention period was 6 months in both groups. The frequencies of seizures were determined from parental reports and were compared between the groups. The patients with upper than 50% reduction in seizure frequency were deemed as responders to the diets. Twenty-four patients were assigned to the KD and 11 patients to the MAD. Overall, 45.8% of children treated with the KD and 45.5% of children treated with MAD had over than 50% response to the diet therapies. The difference was not statistically significant (P = 0.437). The MAD was more advantageous regarding better tolerability and fewer side effects. There is not much difference regarding the efficacy between the MAD and classic KD. The MAD with fewer side effects may be more suitable as the first line of dietary therapy in children with refractory epilepsy. |
| Databáze: | OpenAIRE |
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