Clinical Characteristics and Outcomes of Immunocompromised Patients With Coronavirus Disease 2019 Caused by the Omicron Variant: A Prospective, Observational Study

Autor: S Reshwan K Malahe, Rogier A S Hoek, Virgil A S H Dalm, Annoek E C Broers, Caroline M den Hoed, Olivier C Manintveld, Carla C Baan, Charlotte M van Deuzen, Grigorios Papageorgiou, Hannelore I Bax, Jeroen J Van Kampen, Merel E Hellemons, Marcia M L Kho, Rory D de Vries, Richard Molenkamp, Marlies E J Reinders, Bart J A Rijnders
Přispěvatelé: Internal Medicine, Pulmonary Medicine, Immunology, Hematology, Gastroenterology & Hepatology, Cardiology, Epidemiology, Medical Microbiology & Infectious Diseases, Virology
Rok vydání: 2022
Předmět:
Zdroj: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 76(3):ciac571, e172-e178. Oxford University Press
ISSN: 1537-6591
1058-4838
DOI: 10.1093/cid/ciac571
Popis: Background Illness after infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant is less severe compared with previous variants. Data on the disease burden in immunocompromised patients are lacking. We investigated the clinical characteristics and outcomes of immunocompromised patients with coronavirus disease 2019 (COVID-19) caused by Omicron. Methods Organ transplant recipients, patients on anti-CD20 therapy, and allogenic hematopoietic stem cell transplantation recipients infected with the Omicron variant were included. Characteristics of consenting patients were collected and patients were contacted regularly until symptom resolution. To identify possible risk factors for hospitalization, a univariate logistic analysis was performed. Results 114 consecutive immunocompromised patients were enrolled. Eighty-nine percent had previously received 3 mRNA vaccinations. While only 1 patient died, 23 (20%) were hospitalized for a median of 11 days. A low SARS-CoV-2 immunoglobulin G (IgG) antibody response ( Conclusions While the mortality in immunocompromised patients infected with Omicron was low, hospital admission was frequent and the duration of symptoms often prolonged. In addition to vaccination, other interventions are needed to limit the morbidity from COVID-19 in immunocompromised patients.
Databáze: OpenAIRE
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