Enteral nutrition volume is not correlated with lower respiratory tract infection in patients on mechanical ventilation
| Autor: | A. Colomar, M. Ferreruela, B. Guardiola, I. Ayestarán, Joan Maria Raurich, J. Rodríguez-Pilar, Juan Antonio Llompart-Pou |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Male
medicine.medical_specialty Critical Illness medicine.medical_treatment Critical Care and Intensive Care Medicine Gastroenterology law.invention 03 medical and health sciences Enteral Nutrition 0302 clinical medicine law Internal medicine Lower respiratory tract infection Humans Medicine 030212 general & internal medicine Respiratory Tract Infections Retrospective Studies Mechanical ventilation Respiratory tract infections business.industry Proportional hazards model Incidence Pneumonia Ventilator-Associated Proton Pump Inhibitors 030208 emergency & critical care medicine Middle Aged medicine.disease Respiration Artificial Intensive care unit Gastrointestinal Tract Pneumonia Parenteral nutrition Anesthesia Female Energy Intake business Gastrointestinal function |
| Zdroj: | Medicina Intensiva (English Edition). 41:330-338 |
| ISSN: | 2173-5727 |
| DOI: | 10.1016/j.medine.2016.09.005 |
| Popis: | Objective To evaluate the effect of enteral nutrition volume, gastrointestinal function and the type of acid suppressive drug upon the incidence of lower respiratory tract infections in critically ill patients on mechanical ventilation (MV). Design A retrospective secondary analysis was carried out. Setting The Intensive Care Unit of a University Hospital. Patients or participants Patients ≥ 18-years-old expected to need MV for more than four days, and receiving enteral nutrition by nasogastric tube within 24 h of starting MV. Interventions We correlated enteral nutrition volume administered during the first 10 days, gastrointestinal function and the type of acid suppressive therapy with the episodes of lower respiratory tract infection up until day 28. Cox proportional hazards ratios in univariate and adjusted multivariate models were used. Statistical significance was considered for p Main variables of interest Lower respiratory tract infection episodes. Results Sixty-six out of 185 patients (35.7%) had infection; 27 patients had ventilator-associated pneumonia; and 39 presented ventilator-associated tracheobronchitis. Uninfected and infected groups were similar in terms of enteral nutrition volume (54 ± 12 and 54 ± 9 mL/h; p = 0.94) and caloric intake (19.4 ± 4.9 and 19.6 ± 5.2 kcal/kg/d; p = 0.81). The Cox proportional hazards model showed neurological indication of MV to be the only independent variable related to infection (p = 0.001). Enteral nutrition volume, the type of acid suppressive therapy, and the use of prokinetic agents were not significantly correlated to infection. Conclusions Enteral nutrition volume and caloric intake, gastrointestinal dysfunction and the type of acid suppressive therapy used were not associated to lower respiratory tract infection in patients on MV. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect